Yuan Chang, MD
Professor of Pathology
Dr. Chang is a Co-Director of the Tumor Virology Laborotory at the University of Pittsburgh Cancer Institute and a member of the Cellular and Molecular Pathology Graduate Training Program.
Hillman Cancer Research Pavilion
5117 Centre Ave
Office Telephone: 412-623-7721
Lab Telephone: 412-623-7733
- BS - 1981, Stanford University
- MD - 1987, University of Utah
Our laboratory performs basic and applied research on viral oncogenesis with efforts focused in the following three areas:
Merkel cell carcinoma and Merkel cell polyomavirus. We recently discovered a new human polyomavirus that we call Merkel cell polyomavirus (MCV). This virus is etiologically associated with a rare, but one of the most clinically aggressive skin cancers in humans. We are currently investigating the transforming properties of this virus and its encoded oncogenes.
Kaposi's sarcoma-associated herpesvirus. We are investigating biologic properties of KSHV, the eighth human herpesvirus, also identified in our laboratory. KSHV causes Kaposi's sarcoma, the most common AIDS-associated malignancy, as well as a B-cell lymphoma. Through extensive molecular piracy, the virus has incorporated numerous genes which affect cell proliferation pathways, apoptosis, cell cycle regulation and immune modulation.
New Pathogen Discovery. We continue to be interested in the search for new pathogens in human diseases and have developed new methodologies, which utilize information gained from the Human Genome Project, as well as advanced sequencing technologies.
- 2002 - Pennsylvania State Medical License: # MD420450
- 1995 - American Board of Pathology: Anatomic Pathology/Neuropathology (AP/NP)
- 1993 - New York State Medical License: # 193413
- 1988 - National Board of Medical Examiners
- Anatomic Pathology/Neuropathology
- Viral Oncology
Awards and Honors
- 1994 - Clinical Trials Research Award, Columbia Presbyterian Hospital, NY, NY
- 1995 - James S. McDonnell Scholar, McDonnell Foundation, St. Louis, Missouri
- 1997 - Lamport Award for Excellence in Clinical Science Research, Columbia University College of Phys & Surg, NY, NY
- 1997 - Meyenburg Award, Meyenburg Foundation for Cancer Research German Cancer Research Center, Heidelberg, Germany
- 1998 - Robert Koch Prize, Robert Koch Foundation, Bonn, Germany
- 1999 - Mayor's Award for Excellence in Science & Technology, NY, NY
- 2003 - Charles S. Mott Award, General Motors Cancer Research Foundation
- 2003 - Paul Marks Prize, Memorial Sloan Kettering Cancer Research, NY, NY
- 2004 - American Society for Clinical Investigation, Elected Member
- 2008 - American Cancer Society Research Professorship
- 2009 - Carnegie Life Sciences Award
- 2010 - American Academy of Microbiology, Elected Fellow
- 2012 - Marjorie Stephenson Prize, Society of General Microbiology
- 2012 - Chancellor's Distinguished Research Award, University of Pittsburgh
- 2012 - National Academy of Sciences, Elected Member
Selected PublicationsView Dr. Chang's publications on PubMed
- Shuda M, Chang Y, Moore, PS. Merkel Cell Polyomavirus Positive Merkel Cell Carcinoma Requires Viral Small T Antigen For Cell Proliferation. JID 2014; 134(5):1479-81.
- Moore PS, Chang Y. the Conundrum of Causality in Tumor Virology: The Cases of KSHV and MCV. Semin Cancer Biol. 2014 Jun:26:4-12.
- Shuda M, Velásquez C, Cheng E, Cordek DG, Kwun HJ, Chang Y, Moore PS. CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation. Proc Natl Acad Sci U S A. 2015 May 12;112(19):5875-82.
- Ho J, Jedrych JJ, Feng H, Natalie AA, Grandinetti L, Miryish E, Crespo MM, Yadav D, Fasanella KE, Proskell S, Kuan SF, Pastrana DV, Buck CB, Shuda Y, Moore PS, Chang Y. Human Polyomavirus 7-associated Pruritic Rash and Viremia in Transplant Recipients. J Infect Dis 2015 May 15;211(10):1560-5.
- Kwun HJ, Shuda M, Camacho CJ, Gamper AM, Thant M, Chang Y, Moore PS. Restricted protein phosphatase 2A targeting by Merkel cell polyomavirus small T antigen. J Virol. 2015 Apr;89(8):4191-200.
- Wendzicki JA, Moore PS, Chang Y. Large T and Small T Antigens of Merkel Cell Polyomavirus. Curr Opin Virol 2015 Feb 11;11C:38-43.
- Kwun HJ, Toptan T, Ramos da Silva S, Atkins JF, Moore PS, Chang Y. Human DNA Tumor Viruses Generate Alternative Reading Frame Proteins Through Repeat Sequence Coding. Proc Nat Acad Sci U S A 2014 Oct 14;111(41):E4342-9.