Yvonne R. Chan, MD
Assistant Professor of Medicine
Dr. Chan is a member of the Division of Pulmonary, Allergy, and Critical Care Medicine and a member of the Cellular and Molecular Pathology Graduate Training Program.
3459 Fifth Avenue
Pittsburgh, PA 15213
Office Telephone: 412-864-3199
- MD - Harvard-MIT Health Sciences and Technology Program (HST)
Research InterestsDr. Chan's research focuses on the innate immune response to Gram negative pneumonias that commonly afflict patients who are immunocompromised with conditions such as cystic fibrosis, HIV, chronic alcoholism and the critically ill. Her studies focus on identifying antimicrobial proteins synthesized by the host in response to these infections, characterizing their mechanism of action and their interaction with the host immune response.
Awards and Honors2008 - Howard Hughes Medical Institute Early Career Physician-Scientist Award
Selected PublicationsView Dr. Chan's publications on PubMed
Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, Chan YR, Ouyang W, Brown GD, Weaver CT, Steele C. Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus. Infect Immun. 2012 Jan;80(1):410-7. Epub 2011 Oct 28. PMCID: 3255669.
Li C, Chan YR. Lipocalin 2 regulation and its complex role in inflammation and cancer. Cytokine. 2011 Nov;56(2):435-41. Epub 2011 Aug 19. Review. PMID: 21855366.
Chen K, Pociask DA, McAleer JP, Chan YR, Alcorn JF, Kreindler JL, Keyser MR, Shapiro SD, Houghton AM, Kolls JK, Zheng M. IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS One. 2011;6(5):e20333. Epub 2011 May 27. PMID: 21647421.
Kreindler JL, Steele C, Nguyen N, Chan YR, Pilewski JM, Alcorn JF, Vyas YM, Aujla SJ, Finelli P, Blanchard M, Zeigler SF, Logar A, Hartigan E, Kurs-Lasky M, Rockette H, Ray A, Kolls JK. Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis. J Clin Invest. 2010 Sep;120(9):3242-54. doi: 10.1172/JCI42388. Epub 2010 Aug 16.