Patricia A. Hebda, PhD
Professor of Otolaryngology and Pathology
Adjunct Professor of Speech and Communication Disorders
Dr. Hebda is the Director of the Otolaryngology Wound Healing Research Program at Children's Hospital of Pittsburgh. In addition, she is an associate faculty member of the Pittsburgh Tissue Engineering Initiative, a member of the McGowan Institute for Regenerative Medicine, and a member of the Cellular and Molecular Pathology Graduate Training Program.
Rangos Research Center, Room 5120
4401 Penn Avenue Pittsburgh, PA 15224
Office Telephone: 412-692-6217
- BS - Michigan State University
- PhD - Ohio State University
Research InterestsDr. Hebda is focusing her research on three main areas: wound healing and tissue engineering for applications in the head and neck, which aims to develop new, biologically-driven therapeutic modalities to promote and optimize wound healing of the upper digestive system; pathogenesis of inflammation in otitis media, which focuses upon understanding the molecular signaling associated with mucosal inflammation using animal models of acute otitis media, otitis media with effusion (induced by Eustachian tube obstruction), and chronic suppurative otitis media; and, applications for improving wound care and enhancing healing, which posits that the development of fibrosis can be prevented by blunting early wound-healing events leading to fibroblast recruitment and activation of their synthetic properties.
Selected PublicationsView Dr. Hebda's publications on PubMed
Li NY, Abbott KV, Rosen C, An G, Hebda PA, Vodovotz Y. Translational systems biology and voice pathophysiology. Laryngoscope. 2010 Mar;120(3):511-5. Review. PMCID: 3032590.
Singh T, Sandulache VC, Otteson TD, Barsic M, Klein EC, Dohar JE, Hebda PA. Subglottic stenosis examined as a fibrotic response to airway injury characterized by altered mucosal fibroblast activity. Archives of Otolaryngology. Head and Neck Surgery. 2010 Feb;136(2):163-70. PMC3000122.
Sandulache VC, Singh T, Li-Korotky HS, Lo CY, Otteson TD, Barsic M, Dohar JE, Hebda PA. Prostaglandin E2 is activated by airway injury and regulates fibroblast cytoskeletal dynamics. Laryngoscope. 2009 Jul;119(7):1365-73. PMCID: 3000119
Parekh A, Mantle B, Banks J, Swarts JD, Badylak SF, Dohar JE, Hebda PA. Repair of the tympanic membrane with urinary bladder matrix. Laryngoscope. Epub 2009 Apr 8. PMCID: 3003594.
Parekh A, Sandulache VC, Singh T, Cetin S, Sacks MS, Dohar JE, Hebda PA. Prostaglandin E2 differentially regulates contraction and structural reorganization of anchored collagen gels by human adult and fetal dermal fibroblasts. Wound Repair and Regeneration. 2009 Jan-Feb;17(1):88-98. PMCID: 3000117.
Yates CC, Whaley D, Hooda S, Hebda PA, Bodnar RJ, Wells A. Delayed reepithelialization and basement membrane regeneration after wounding in mice lacking CXCR3. Wound Repair and Regeneration. 2009 Jan-Feb;17(1):34-41. PMCID: 2928121.