Yoram Vodovotz, PhD
Professor of Surgery



Dr. Vodovotz is the Director of the Center for Inflammation and Regenerative Modeling at the McGowan Institute for Regenerative Medicine and a member of the Cellular and Molecular Pathology Graduate Training Program.

Office Location:
W944 Biomedical Sciences Tower
200 Lothrop Street
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-648-3758
Email: vodovotzy@upmc.edu

Education

  • PhD - Cornell University Graduate School of Medical Sciences, 1993

Research Interests

My research interests are centered on systems approaches to the biology of shock states (e.g. septic and hemorrhagic shock), host-pathogen interactions (especially in malaria), wound healing, and chronic inflammatory diseases. As the Director of the Center for Inflammation and Regenerative Modeling (CIRM) at the McGowan Institute for Regenerative Medicine, I have been involved in the mathematical modeling of shock states (e.g. septic or hemorrhagic shock), including cellular and physiological elements, as part of a large, interdisciplinary collaborative team. I am also interested in the cross-regulation of the inducible nitric oxide synthase (iNOS) and the cytokine transforming growth factor-beta-1 (TGF-β1) in various disease states, including malaria infection, cancer, sepsis, and neurodegenerative diseases.

Selected Publications

View Dr. Vodovotz's publications on PubMed

  1. Mi, Q.; Constantine, G.; Ziraldo, C.; Solovyev, A.; Torres, A.; Namas, R.; Bentley, T.; Billiar, T.R.; Zamora, R.; Puyana, J.C.; Vodovotz, Y. A dynamic view of trauma/hemorrhage-induced inflammation in mice: Principal drivers and networks. PLoS ONE. 2011. 2011.6:19424. PMCID: PMC3091861

  2. Nieman, G.; Brown, D.; Sarkar, J.; Kubiak, B.; Ziraldo, C.; Vieau, C.; Barclay, D.; Gatto, L.; Maier, K.; Zamora, R.; Mi, Q.; Chang, S.; Vodovotz, Y. A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine. Crit. Care Med. 2012. 40:1052-1063. PMCID: PMC3308118

  3. Zamora, R.; Metukuri, M.R.; Nammas, R.; Azhar, N.; Clermont, T.; Constantine, G.; Gladstone, C.; Jefferson, B.; Barclay, D.; Hermus, L.; Loughran, P.; Billiar, T.R.; Fink, M.P.; Delude, R.; Vodovotz, Y. Induction and activation of macrophage transforming growth factor- 1 by extracellular NAD+ and its metabolite, cADPR. J. Biol. Chem. 2012. 287:31003-31014. PMCID: PMC3438933

  4. Namas, R.; Mikheev, M.; Yin, J.; Over, P.; Young, M.; Constantine, G.; Zamora, R.; Gerlach, J.; Vodovotz, Y. A biohybrid device for the systemic control of acute inflammation. Disrupt. Science & Technol. 2012.1:20-27.

  5. Azhar, N.; Ziraldo, C.; Barclay, D.; Rudnick, D.; Squires, R.; Vodovotz, Y. Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure. PLoS ONE. 2013. 8:e78202.

  6. Namas, R.A.; Bartels, J.; Hoffman, R.; Barclay, D.; Billiar, T.R.; Zamora, R.; Vodovotz, Y. Combined in silico, in vivo, and in vitro studies shed insights into the acute inflammatory response in middle-aged mice. 2013. PLoS ONE. 2013. 8: e67419. PMCID: PMC3699569

  7. Vodovotz, Y.; Billiar, T.R. In silico modeling: Methods and applications to trauma and sepsis. Crit. Care Med. 2013. 41:2008-2014. PMCID: PMC3722589

  8. Solovyev, A.; Mi, Q.; Tzen, Y-T.; Brienza, D.; Vodovotz, Y. Hybrid equation- / agent-based model of ischemia-induced hyperemia and pressure ulcer formation predicts greater propensity to ulcerate in subjects with spinal cord injury. PLoS Comput. Biol. 2013. 9:e1003070. PMCID: PMC3656105

  9. Complex Systems and Computational Biology Approaches to Acute Inflammation. An, G.; Vodovotz, Y., eds. New York, NY: New York, NY: Springer. 2013. http://dx.doi.org/10.1007/978-1-4614-8008-2