Stephen F. Badylak, DVM, PhD, MD
Professor of Surgery



Dr. Badylak is a Professor, Department of Surgery; Professor, Department of Bioengineering; Deputy Director, McGowan Institute for Regenerative Medicine

Office Location:
McGowan Institute for Regenerative Medicine
Bridgeside Point II, Suite 300
450 Technology Drive
Pittsburgh, PA 15219-3143
Contact Information:
Office Telephone: 412-624-5253 or 5252
Lab Telephone: 412-624-5272
Email: badylaks@upmc.edu

Education

  • DVM - 1976, Purdue University
  • MS - 1978, Purdue University
  • PhD - 1981, Purdue University
  • MD - 1985, Indiana University

Clinical Expertise

Dr. Badylak practiced primary care and sports medicine for sixteen years and served as the head Team Physician for Purdue University during this tenure.

ResearchExpertise

The Badylak laboratory is focused upon the development and clinical translation of biologic scaffolds for functional tissue reconstruction. There is a heavy emphasis upon the interdisciplinary and translational aspects of regenerative medicine. All studies of bioscaffold remodeling, including those investigating the host innate immune response, gene transcription of responding cells, metabolic pathways, and the molecular effectors of cell phenotype are conducted with the end point of patient care in mind. Our studies involve several forms of biologic scaffolds which typically are composed of xenogenic mammalian extracellular matrix; including whole organ 3-dimensional scaffolds derived by organ decellularization. Genetic profiling, proteomics, cell matrix interactions, in-vitro cell culture, biomechanical testing, preclinical animal studies, and human clinical studies are actively pursued in the laboratory (Dr. Badylak is currently the PI on one active clinical trial focused upon musculotendinous tissue reconstruction). The laboratory is interdisciplinary by design and therefore close communication among all members of the research team is vital to success. The laboratory consists of approximately 6 staff scientists, 4 - 5 postdoctoral fellows, 6 predoctoral students (including about 50% MD/PhD students), 3 - 5 undergraduate students, a technical support staff, and an administrative support staff. All members of the laboratory are keenly aware of meeting milestones and all are exposed to a productive mixture of industry sponsored research and federally funded basic science research. My interest in the utilization of biologic scaffolds, including the preparation and characterization of such scaffolds, spans more than 25 years. Four million plus human patients have now been successfully treated with scaffold materials developed by our laboratory.

Specialties

  • Tissue Engineering/Regenerative Medicine
  • Biologic Scaffolds and Extracellular Matrix Biology
  • Biomaterials and Host-Biomaterial Interactions
  • Host Immune Response and Role in Remodeling of Biomaterials
  • Orthopaedic Surgery and Biology, Soft Tissue and Limb Regeneration
  • Biomedical Engineering as it Relates to Device Development and Biomaterials

Awards and Honors

  • Founding Fellow of the International Fellows of Tissue Engineering & Regenerative Medicine (FTERM) - 2012
  • TERMIS (America's Chapter) Senior Scientist Award - 2012
  • Oscar W. Shalm Lectureship Series Award - 2011
  • Innovation Award (University of Pittsburgh) - 2008
  • Inventor of the Year Award (Pittsburgh Intellectual Property Law Association) - 2008
  • Chancellor's Distinguished Research Award (Senior Scholars category) - 2008
  • Carnegie Science Center Award for Excellence (Biomaterials) - 2008
  • Carnegie Science Center Award for Excellence (Research) - 2005
  • Clemson Award (Society for Biomaterials) - 2005
  • Sigma Xi (Scientific Research Society - Research Award) - 2002

Selected Publications

View Dr. Badylak's publications on PubMed

  1. Mase VJ, Jr., Hsu JR, Wolf SE, Wenke JC, Baer DG, Owens J, Badylak SF, Walters TJ. Clinical application of an acellular biologic scaffold for surgical repair of a large, traumatic quadriceps femoris muscle defect. Orthopedics, 2011. 33 (7): 511. PMID: 20608620. PMCID: NA.
  2. Huber A, Boruch AV, Nieponice A, Jiang H, Medberry C, Badylak SF. Histopathologic host response to polypropylene-based surgical mesh materials in a rat abdominal wall defect model. J Biomed Mater Res B Appl Biomater, 2012. 100 (3): 709-717. PMID: 22128072. PMCID: NA.
  3. Wearden PD, Morell VO, Keller BB, Webber SA, Borovetz HS, Badylak SF, Boston JR, Kormos RL, Kameneva MV, Simaan M, Snyder TA, Tsukui H, Wagner WR, Antaki JF, Diao C, Vandenberghe S, Gardiner J, Li CM, Noh D, Paden D, Paden B, Wu J, Bearnson GB, Jacobs G, Kirk J, Khanwilkar P, Long JW, Miles S, Hawkins JA, Kouretas PC, Shaddy RE. The PediaFlow pediatric ventricular assist device. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2006:92-8. Review. PubMed PMID: 16638553.
  4. Tottey S, Corselli M, Jeffries EM, Londono R, Peault B, Badylak SF. Extracellular matrix degradation products and low-oxygen conditions enhance the regenerative potential of perivascular stem cells. Tissue Eng Part A, 2011. 17 (1-2): 37-44. PMID: 20653348. PMCID: 3011908.
  5. Hammond JS, Gilbert TW, Howard D, Zaitoun A, Michalopoulos G, Shakesheff KM, Beckingham IJ, Badylak SF. Scaffolds containing growth factors and extracellular matrix induce hepatocyte proliferation and cell migration in normal and regenerating rat liver. J Hepatol, 2011. 54 (2): 279-287. PMID: 21126791. PMCID: NA.
  6. Mazzitelli S, Luca G, Mancuso F, Calvitti M, Calafiore R, Nastruzzi C, Johnson S, Badylak SF. Production and characterization of engineered alginate-based microparticles containing ECM powder for cell/tissue engineering applications. Acta Biomater, 2011. 7 (3): 1050-1062. PMID: 20950716. PMCID: NA.
  7. Wainwright JM, Hashizume R, Fujimoto KL, Remlinger NT, Pesyna C, Wagner WR, Tobita K, Gilbert TW, Badylak SF. Right ventricular outflow tract repair with a cardiac biologic scaffold. Cells Tissues Organs, 2012. 195 (1-2): 159-170. PMID: 22025093. PMCID: 3325605.
  8. Brown BN, Chung WL, Pavlick M, Reppas S, Ochs MW, Russell AJ, Badylak SF. Extracellular matrix as an inductive template for temporomandibular joint meniscus reconstruction: a pilot study. J Oral Maxillofac Surg, 2011. 69 (12): e488-505. PMID: 21684655. PMCID: NA.
  9. Brown BN, Freund JM, Han L, Rubin JP, Reing JE, Jeffries EM, Wolf MT, Tottey S, Barnes CA, Ratner BD, Badylak SF. Comparison of three methods for the derivation of a biologic scaffold composed of adipose tissue extracellular matrix. Tissue Eng Part C Methods, 2011. 17 (4): 411-421. PMID: 21043998. PMCID: 3065729.
  10. Huber A, Badylak SF. Phenotypic changes in cultured smooth muscle cells: limitation or opportunity for tissue engineering of hollow organs? J Tissue Eng Regen Med, 2011. PMID: 21755602. PMCID: 3237740.
  11. Barnes CA, Brison J, Michel R, Brown BN, Castner DG, Badylak SF, Ratner BD. The surface molecular functionality of decellularized extracellular matrices. Biomaterials, 2011. 32 (1): 137-143. PMID: 21055805. PMCID: 2997685.
  12. Badylak SF, Brown BN, Gilbert TW, Daly KA, Huber A, Turner NJ. Biologic scaffolds for constructive tissue remodeling. Biomaterials, 2011. 32 (1): 316-319. PMID: 21125721. PMCID: NA.
  13. Tottey S, Johnson SA, Crapo PM, Reing JE, Zhang L, Jiang H, Medberry CJ, Reines B, Badylak SF. The effect of source animal age upon extracellular matrix scaffold properties. Biomaterials, 2011. 32 (1): 128-136. PMID: 20870285. PMCID: 2987535.
  14. Soto-Gutierrez A, Zhang L, Medberry C, Fukumitsu K, Faulk D, Jiang H, Reing J, Gramignoli R, Komori J, Ross M, Nagaya M, Lagasse E, Stolz D, Strom SC, Fox IJ, Badylak SF. A whole-organ regenerative medicine approach for liver replacement. Tissue Eng Part C Methods, 2011. 17 (6): 677-686. PMID: 21375407. PMCID: 3103054.
  15. Badylak SF, Hoppo T, Nieponice A, Gilbert TW, Davison JM, Jobe BA. Esophageal preservation in five male patients after endoscopic inner-layer circumferential resection in the setting of superficial cancer: a regenerative medicine approach with a biologic scaffold. Tissue Eng Part A, 2011. 17 (11-12): 1643-1650. PMID: 21306292. PMCID: 3098955.
  16. Badylak SF, Taylor D, Uygun K. Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds. Annu Rev Biomed Eng, 2011. 13 27-53. PMID: 21417722. PMCID: NA.
  17. Brown BN, Chung WL, Almarza AJ, Pavlick MD, Reppas SN, Ochs MW, Russell AJ, Badylak SF. An Inductive, Scaffold-Based, Regenerative Medicine Approach to Reconstruction of the Temporomandibular Joint Disk. J Oral Maxillofac Surg, 2012. PMID: 22365981. PMCID: 3368066.
  18. Marongiu F, Gramignoli R, Dorko K, Miki T, Ranade AR, Paola Serra M, Doratiotto S, Sini M, Sharma S, Mitamura K, Sellaro TL, Tahan V, Skvorak KJ, Ellis EC, Badylak SF, Davila JC, Hines R, Laconi E, Strom SC. Hepatic differentiation of amniotic epithelial cells. Hepatology, 2011. 53 (5): 1719-1729. PMID: 21374689. PMCID: 3103747.
  19. Agrawal V, Tottey S, Johnson SA, Freund JM, Siu BF, Badylak SF. Recruitment of progenitor cells by an extracellular matrix cryptic peptide in a mouse model of digit amputation. Tissue Eng Part A, 2011. 17 (19-20): 2435-2443. PMID: 21563860. PMCID: 3179613.
  20. Daly KA, Wolf M, Johnson SA, Badylak SF. A rabbit model of peripheral compartment syndrome with associated rhabdomyolysis and a regenerative medicine approach for treatment. Tissue Eng Part C Methods, 2011. 17 (6): 631-640. PMID: 21361746. PMCID: NA
  21. Turner NJ, Pezzone MA, Brown BN, Badylak SF. Quantitative multispectral imaging of Herovici's polychrome for the assessment of collagen content and tissue remodelling. J Tissue Eng Regen Med, 2011. PMID: 22072426. PMCID: NA.
  22. Crapo PM, Gilbert TW, Badylak SF. An overview of tissue and whole organ decellularization processes. Biomaterials, 2011. 32 (12): 3233-3243. PMID: 21296410. PMCID: 3084613.
  23. Hong Y, Huber A, Takanari K, Amoroso NJ, Hashizume R, Badylak SF, Wagner WR. Mechanical properties and in vivo behavior of a biodegradable synthetic polymer microfiber-extracellular matrix hydrogel biohybrid scaffold. Biomaterials, 2011. 32 (13): 3387-3394. PMID: 21303718. PMCID: 3184831.
  24. Gilbert TW, Badylak SF, Beckman EJ, Clower DM, Rubin JP. Prevention of seroma formation with TissuGluŽ surgical adhesive in a canine abdominoplasty model: long term clinical and histologic studies. J Plast Reconstr Aesthet Surg. 2013 Mar;66(3):414-22. doi: 10.1016/j.bjps.2012.09.029. Epub 2012 Oct 31. PubMed PMID: 23122707. PMCID: NA.
  25. Ribeiro AJ, Tottey S, Taylor RW, Bise R, Kanade T, Badylak SF, Dahl KN. Mechanical characterization of adult stem cells from bone marrow and perivascular niches. J Biomech, 2012. 45 (7): 1280-1287. PMID: 22349118. PMCID: 3327761.
  26. Turner NJ, Badylak SF. Regeneration of skeletal muscle. Cell Tissue Res, 2012. 347 (3): 759-774. PMID: 21667167. PMCID: NA.
  27. Huber A, McCabe GP, Boruch AV, Medberry C, Honerlaw M, Badylak SF. Polypropylene-containing synthetic mesh devices in soft tissue repair: a meta-analysis. J Biomed Mater Res B Appl Biomater, 2012. 100 (1): 145-154. PMID: 22102367. PMCID: NA.
  28. Agrawal V, Kelly J, Tottey S, Daly KA, Johnson SA, Siu BF, Reing J, Badylak SF. An isolated cryptic Peptide influences osteogenesis and bone remodeling in an adult Mammalian model of digit amputation. Tissue Eng Part A, 2011. 17 (23-24): 3033-3044. PMID: 21740273. PMCID: 3226059.
  29. Brown BN, Londono R, Tottey S, Zhang L, Kukla KA, Wolf MT, Daly KA, Reing JE, Badylak SF. Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials. Acta Biomater, 2012. 8 (3): 978-987. PMID: 22166681. PMCID: NA. NIHMSID: 346364
  30. Hong Y, Takanari K, Amoroso NJ, Hashizume R, Brennan-Pierce EP, Freund JM, Badylak SF, Wagner WR. An elastomeric patch electrospun from a blended solution of dermal extracellular matrix and biodegradable polyurethane for rat abdominal wall repair. Tissue Eng Part C Methods, 2012. 18 (2): 122-132. PMID: 21933017. PMCID: 3262977.
  31. Sanz AF, Hoppo T, Witteman BP, Brown BN, Gilbert TW, Badylak SF, Nieponice A. In-vivo Assessment of a Biologic Occluder for NOTES Gastrotomy Closure. Surg Lap Endosc Percut Tech, PMID: (In Press August 2012). PMCID: NA.
  32. Marcal H, Ahmed T, Badylak SF, Tottey S, Foster LJ. A comprehensive protein expression profile of extracellular matrix biomaterial derived from porcine urinary bladder. Regen Med, 2012. 7 (2): 159-166. PMID: 22397606. PMCID: NA.
  33. Daly KA, Liu S, Agrawal V, Brown BN, Johnson SA, Medberry CJ, Badylak SF. Damage associated molecular patterns within xenogeneic biologic scaffolds and their effects on host remodeling. Biomaterials, 2012. 33 (1): 91-101. PMID: 21967802. PMCID: NA.
  34. Daly KA, Liu S, Agrawal V, Brown BN, Huber A, Johnson SA, Reing J, Sicari B, Wolf M, Zhang X, Badylak SF. The host response to endotoxin-contaminated dermal matrix. Tissue Eng Part A, 2012. 18 (11-12): 1293-1303. PMID: 22416916. PMCID: NA.
  35. Turner NJ, Badylak JS, Weber DJ, Badylak SF. Biologic scaffold remodeling in a dog model of complex musculoskeletal injury. J Surg Res. 2012 Aug;176(2):490-502. doi: 10.1016/j.jss.2011.11.1029. Epub 2011 Dec 15. PubMed PMID: 22341350. PMCID: NA.
  36. Keane TJ, Londono R, Turner NJ, Badylak SF. Consequences of ineffective decellularization of biologic scaffolds on the host response. Biomaterials, 2012. 33 (6): 1771-1781. PMID: 22137126. PMCID: NA.
  37. Penolazzi L, Mazzitelli S, Vecchiatini R, Torreggiani E, Lambertini E, Johnson S, Badylak SF, Piva R, Nastruzzi C. Human mesenchymal stem cells seeded on extracellular matrix-scaffold: viability and osteogenic potential. J Cell Physiol, 2012. 227 (2): 857-866. PMID: 21830215. PMCID: NA.
  38. Badylak SF, Weiss DJ, Caplan A, Macchiarini P. Engineered whole organs and complex tissues. Lancet, 2012. 379 (9819): 943-952. PMID: 22405797. PMCID: NA.
  39. Turner WS, Wang X, Johnson S, Medberry C, Mendez J, Badylak SF, McCord MG, McCloskey KE. Cardiac tissue development for delivery of embryonic stem cell-derived endothelial and cardiac cells in natural matrices. J Biomed Mater Res B Appl Biomater. 2012 Nov;100(8):2060-72. doi: 10.1002/jbm.b.32770. Epub 2012 Aug 11. PubMed PMID: 22888031. PMCID: NA.
  40. Nieponice A, Gilbert TW, Johnson SA, Turner NJ, Badylak SF. Bone marrow-derived cells participate in the long-term remodeling in a mouse model of esophageal reconstruction. J Surg Res. 2013 Jun 1;182(1):e1-7. PubMed PMID: 23069684. PMCID: NA.
  41. Agrawal V, Siu BF, Chao H, Hirschi KK, Raborn E, Johnson SA, Tottey S, Hurley KB, Medberry CJ, Badylak SF. Partial Characterization of the Sox2+ Cell Population in an Adult Murine Model of Digit Amputation. Tissue Eng Part A, 2012. PMID: 22530556. PMCID: 3397117.
  42. Sicari BM, Agrawal V, Siu BF, Medberry CJ, Dearth CL, Turner NJ, Badylak SF. A murine model of volumetric muscle loss and a regenerative medicine approach for tissue replacement. Tissue Eng Part A, 2012. 18 (19-20): 1941-1948. PMID: 22906411. PMCID: 3463275.
  43. Wolf MT, Daly KA, Reing JE, Badylak SF. Biologic scaffold composed of skeletal muscle extracellular matrix. Biomaterials, 2012. 33 (10): 2916-2925. PMID: 22264525. PMCID: NA.
  44. Bible E, Dell'Acqua F, Solanky B, Balducci A, Crapo PM, Badylak SF, Ahrens ET, Modo M. Non-invasive imaging of transplanted human neural stem cells and ECM scaffold remodeling in the stroke-damaged rat brain by (19)F- and diffusion-MRI. Biomaterials, 2012. 33 (10): 2858-2871. PMID: 22244696. PMCID: 3268910.
  45. Turner NJ, Badylak SF. Biologic scaffolds for musculotendinous tissue repair. Eur Cell Mater. 2013 Jan 18;25:130-43. PubMed PMID: 23329468. PMCID: NA.
  46. Crapo PM, Medberry CJ, Reing JE, Tottey S, van der Merwe Y, Jones KE, Badylak SF. Biologic scaffolds composed of central nervous system extracellular matrix. Biomaterials, 2012. 33 (13): 3539-3547. PMID: 22341938. PMCID: 3516286.
  47. Brown BN, Ratner BD, Goodman SB, Amar S, Badylak SF. Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine. Biomaterials, 2012. 33 (15): 3792-3802. PMID: 22386919. PMCID: 3727238.
  48. Hoppo T, Badylak SF, Jobe BA. A novel esophageal-preserving approach to treat high-grade dysplasia and superficial adenocarcinoma in the presence of chronic gastroesophageal reflux disease. World J Surg. 2012 Oct;36(10):2390-3. doi: 10.1007/s00268-012-1698-6. PubMed PMID: 22736346. PMCID: NA.
  49. Sicari BM, Johnson SA, Siu BF, Crapo PM, Daly KA, Jiang H, Medberry CJ, Tottey S, Turner NJ, Badylak SF. The effect of source animal age upon the in vivo remodeling characteristics of an extracellular matrix scaffold. Biomaterials, 2012. 33 (22): 5524-5533. PMID: 22575834. PMCID: 3569720.
  50. Londono R, Jobe BA, Hoppo T, Badylak SF. Esophagus and regenerative medicine. World J Gastroenterol. 2012 Dec 21;18(47):6894-9. doi: 10.3748/wjg.v18.i47.6894. PMID: 23322986. PMCID: 3531672.
  51. Wolf MT, Daly KA, Brennan-Pierce EP, Johnson SA, Carruthers CA, D'Amore A, Nagarkar SP, Velankar SS, Badylak SF. A hydrogel derived from decellularized dermal extracellular matrix. Biomaterials, 2012. 33 (29): 7028-7038. PMID: 22789723. PMCID: 3408574.
  52. Zhang L, Zhang F, Weng Z, Brown BN, Yan H, Ma XM, Vosler PS, Badylak SF, Dixon CE, Cui XT, Chen J. Effect of an inductive hydrogel composed of urinary bladder matrix upon functional recovery following traumatic brain injury. Tissue Eng Part A. 2013 Sep;19(17-18):1909-18. PubMed PMID: 23596981; PMCID: PMC3726021.
  53. Burk J, Badylak SF, Kelly J, Brehm W. Equine cellular therapy-from stall to bench to bedside? Cytometry A. 2013 Jan;83(1):103-13. PubMed PMID: 23081833. PMCID: NA.
  54. Brown BN, Badylak SF. Expanded applications, shifting paradigms and an improved understanding of host-biomaterial interactions. Acta Biomater. 2013 Feb;9(2):4948-55. doi: 10.1016/j.actbio.2012.10.025. Epub 2012 Oct 23. Review. PubMed PMID: 23099303. PMCID: NA.
  55. Keane TJ, Londono R, Carey RM, Carruthers CA, Reing JE, Dearth CL, D'Amore A, Medberry CJ, Badylak SF. Preparation and characterization of a biologic scaffold from esophageal mucosa. Biomaterials. 2013 Sep;34(28):6729-37. doi: 10.1016/j.biomaterials.2013.05.052. Epub 2013 Jun 15. PubMed PMID: 3777917; PubMed Central PMCID: PMC3727430.
  56. Takanari K, Hong Y, Hashizume R, Huber A, Amoroso NJ, D'Amore A, Badylak SF, Wagner WR. Abdominal wall reconstruction by a regionally distinct biocomposite of extracellular matrix digest and a biodegradable elastomer. J Tissue Eng Regen Med. 2013 Dec 27. doi: 10.1002/term.1834. [Epub ahead of print] PubMed PMID: 24376045. PMCID: NA.
  57. Medberry CJ, Crapo PM, Siu BF, Carruthers CA, Wolf MT, Nagarkar SP, Agrawal V, Jones KE, Kelly J, Johnson SA, Velankar SS, Watkins SC, Modo M, Badylak SF. Hydrogels derived from central nervous system extracellular matrix. Biomaterials. 2013 Jan;34(4):1033-40. PMID: 23158935. PMCID: 3512573.
  58. Wang JY, Liou AK, Ren ZH, Zhang L, Brown BN, Cui XT, Badylak SF, Cai YN, Guan YQ, Leak RK, Chen J, Ji X, Chen L. Neurorestorative effect of urinary bladder matrix-mediated neural stem cell transplantation following traumatic brain injury in rats. CNS Neurol Disord Drug Targets. 2013 May 1;12(3):413-25. PubMed PMID: 23469853. PMCID: PMC4049096
  59. Wolf MT, Carruthers CA, Dearth CL, Crapo PM, Huber A, Burnsed OA, Londono R, Johnson SA, Daly KA, Stahl EC, Freund JM, Medberry CJ, Carey LE, Nieponice A, Amoroso NJ, Badylak SF. Polypropylene surgical mesh coated with extracellular matrix mitigates the host foreign body response. J Biomed Mater Res A. 2013 Jul 19. PubMed PMID: 23873846. PMCID: 3808505.
  60. Turner NJ, Londono R, Dearth CL, Culiat CT, Badylak SF. Human NELL1 Protein Augments Constructive Tissue Remodeling with Biologic Scaffolds. Cells Tissues Organs. 2013;198(4):249-65. doi: 10.1159/000356491. PMID: 24335144.
  61. Benders KE, van Weeren PR, Badylak SF, Saris DB, Dhert WJ, Malda J. Extracellular matrix scaffolds for cartilage and bone regeneration. Trends Biotechnol. 2013 Mar;31(3):169-76. PubMed PMID: 23298610.
  62. Nieponice A, Ciotola FF, Nachman F, Jobe BA, Hoppo T, Londono R, Badylak S, Badaloni AE. Patch esophagoplasty: esophageal reconstruction using biologic scaffolds. Ann Thorac Surg. 2014 Jan;97(1):283-8. doi: 10.1016/j.athoracsur.2013.08.011. Epub 2013 Nov 20. PubMed PMID: 24266951.
  63. Sawkins MJ, Bowen W, Dhadda P, Markides H, Sidney LE, Taylor AJ, Rose FR, Badylak SF, Shakesheff KM, White LJ. Hydrogels derived from demineralized and decellularized bone extracellular matrix. Acta Biomater. 2013 Aug;9(8):7865-73. doi: 10.1016/j.actbio.2013.04.029. Epub 2013 Apr 25. PubMed PMID: 23624219; PubMed Central PMCID: PMC3711237.
  64. Crapo PM, Tottey S, Slivka PF, Badylak SF. Effects of biologic scaffolds on human stem cells and implications for CNS tissue engineering. Tissue Eng Part A. 2014 Jan;20(1-2):313-23. doi: 10.1089/ten.TEA.2013.0186. Epub 2013 Oct 10. PubMed PMID: 24004192; PubMed Central PMCID: PMC3875189.
  65. Goh SK, Bertera S, Olsen P, Candiello JE, Halfter W, Uechi G, Balasubramani M, Johnson SA, Sicari BM, Kollar E, Badylak SF, Banerjee I. Perfusion-decellularized pancreas as a natural 3D scaffold for pancreatic tissue and whole organ engineering. Biomaterials. 2013 Sep;34(28):6760-72. doi: 10.1016/j.biomaterials.2013.05.066. Epub 2013 Jun 17. PubMed PMID: 23787110; PMCID: PMC3748589.
  66. Brown BN, Badylak SF. Extracellular matrix as an inductive scaffold for functional tissue reconstruction. Transl Res. 163 (2014), pp. 268-285. PMID: 24291155. PMCID: NA.
  67. Sicari BM, Rubin JP, Dearth CL, Wolf MT, Ambrosio F, Boninger M, Turner NJ, Weber DJ, Simpson TW, Wyse A, Brown EH, Dziki JL, Fisher LE, Brown S, Badylak SF. An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss. Sci Transl Med. 2014 Apr 30;6(234):234ra58. doi: 10.1126/scitranslmed.3008085. PubMed PMID: 24786326. PMCID: NA.
  68. Faulk DM, Carruthers CA, Warner HJ, Kramer CR, Reing JE, Zhang L, D'Amore A, Badylak SF. The effect of detergents on the basement membrane complex of a biologic scaffold material. Acta Biomater. 10 (2014), pp. 183-193 DOI information: 10.1016/j.actbio.2013.09.006. PMID: 24055455. PMCID: 3857635.
  69. Faulk DM, Johnson SA, Zhang L, Badylak SF. Role of the extracellular matrix in whole organ engineering. J Cell Physiol. 2014 Aug;229(8):984-9. doi: 10.1002/jcp.24532. PubMed PMID: 24347365. PMCID: NA.
  70. Keane TJ, Badylak SF. The host response to allogeneic and xenogeneic biological scaffold materials. J Tissue Eng Regen Med. 2014 Feb 18. doi: 10.1002/term.1874. PubMed PMID: 24668694. PMCID: NA.
  71. Modo M, Ambrosio F, Friedlander RM, Badylak SF, Wechsler LR. Bioengineering solutions for neural repair and recovery in stroke. Curr Opin Neurol. 2013 Dec;26(6):626-31. PubMed PMID: 24136127.
  72. Badylak SF. Decellularized Allogeneic and Xenogeneic Tissue as a Bioscaffold for Regenerative Medicine: Factors that Influence the Host Response. Ann Biomed Eng. 2014 Jan 9: 1-11. [Epub ahead of print] PubMed PMID: 24402648.
  73. Sicari BM, Zhang L, Londono R, Badylak SF. An Assay to Quantify Chemotactic Properties of Degradation Products from Extracellular Matrix. Methods Mol Biol. 2013 Oct 24. PMID: 24155230.
  74. Turner NJ, Keane TJ, Badylak SF. Lessons from developmental biology for regenerative medicine. Birth Defects Res C Embryo Today. 2013 Sep;99(3):149-59. doi: 10.1002/bdrc.21040. PubMed PMID: 24078493.
  75. Faulk DM, Wildemann J, Badylak SF. Decellularization and Cell Seeding of Whole Liver Biologic Scaffolds Composed of Extracellular Matrix. Journal of Clinical and Experimental Hepatology (JCEH). (In Press).
  76. Gentile N, Stearns KM, Brown EHP, Rubin JP, Boninger M, Dearth CL, Ambrosio F, Badylak SF. Targeted Rehabilitation following Extracellular Matrix Scaffold Transplantation in Patients with Volumetric Muscle Loss. American Journal of Physical Medicine & Rehabilitation. (In Press).
  77. Meng F, Modo M, Badylak SF. Biologic scaffold for CNS repair. Regen Med. 2014 May;9(3):367-83. doi: 10.2217/rme.14.9. PubMed PMID: 24935046.
  78. Wolf MT, Dearth CL, Ranallo CA, LoPresti ST, Carey LE, Daly KA, Brown BN, Badylak SF. Macrophage polarization in response to ECM coated polypropylene mesh. Biomaterials. 2014 Aug;35(25):6838-49. doi: 10.1016/j.biomaterials.2014.04.115. Epub 2014 May 21. PMID: 24856104.
  79. Chatzistavrou X, Fenno JC, Faulk D, Badylak S, Kasuga T, Boccaccini AR, Papagerakis P. Fabrication and characterization of bioactive and antibacterial composites for dental applications. Acta Biomater. 2014 May 5. pii: S1742-7061(14)00199-8. doi: 10.1016/j.actbio.2014.04.030. PMID: 24802300.
  80. Carey LE, Dearth CL, Johnson SA, Londono R, Medberry CJ, Daly KA, Badylak SF. In Vivo Degradation of 14C-Labeled Porcine Dermis Biologic Scaffold. Biomaterials. (In Press).
  81. Wolf MT, Vodovotz Y, Tottey S, Brown BN, Badylak SF. Predicting In Vivo Responses to Biomaterials via Combined In Vitro and In Silico Analysis. Tissue Engineering, Part C: Methods. (In Press).