Division of Molecular Genomic Pathology

The Division of Molecular Genomic Pathology (MGP) was formed in March 2013 to integrate the clinical, educational and research activities of the previously existing Division of Molecular Anatomic Pathology and Division of Molecular Diagnostics at the Department of Pathology at the University of Pittsburgh Medical Center (UPMC). The newly formed Division is located in the midst of a large hospital complex and performs molecular testing on a variety of clinical sample types over a wide range of diseases using conventional and novel technological approaches such as next generation sequencing. The Division offers more than 70 different molecular tests and processes over 35,000 samples each year in Solid Tumor, Hematologic Malignancies, Infectious Diseases, and Genetics.

Fellowship training opportunities are available for physicians who have completed an accredited residency in Anatomic and/or Clinical Pathology or an accredited residency or fellowship in Medical Genetics.

Faculty with Sign-out Responsibilities

Research Activities

  • Dr. Marie DeFrances studies molecular mechanisms of PI3-kinase signal transduction in hepatocyte proliferation, liver regeneration, metabolism and hepatoceullar cancer using in vitro and in vivo knock-out mouse models.
  • Dr. Zoltan Oltvai’s research interest is in the area of systems biology, focusing on how the functional organization of molecular interaction networks define and constrain cellular functions. He is also interested in translational applications of next generation sequencing in microbiology, oncology and genetic diseases.
  • Dr. Tim Oury investigates the role of reactive oxygen species in pulmonary disease and innate immunity with a focus on how oxidative modification of components of the extracellular matrix contributes to inflammatory responses and pulmonary fibrosis and how the enzyme extracellular superoxide dismutase (EC-SOD) modulates these responses. An additional area of emphasis is the role of the receptor for advanced glycation endproducts (RAGE) in interstitial lung disease and asthma. Dr. Oury co-directs the Department's Pathologist Investigator Residency/Research Training Program to transition physician scientist trainees into academic faculty professorships.

Teaching

  • One-on-one teaching of Pathology Residents, Molecular Genetic Pathology Fellows, and other rotating fellows during daily case signout.
  • Exposure of trainees to technical aspects of laboratory assays and operations via shoulder-to-shoulder interactions with technologists and supervisory staff
  • Supervised assay development and research activities for Molecular Genetic Pathology and Clinical Molecular Genetics Fellows as well as visiting Scholars
  • Weekly Professional Staff/Teaching/Patient Safety Conference employing a broad range of topical material to include clinical cases, assay development, problem-solving in the laboratory, journal club, and research presentations. Residents, Fellows, Faculty and senior laboratory staff participate and present material.
  • Bi-weekly laboratory development meeting for trainees
  • Targeted attendance of Fellows and Residents at clinical genetics clinics for broadened perspective
  • Preparation of abstracts, publications and abstracts with Residents, Fellows, and Visiting Scholars
  • Lectures to Residents, Fellows, medical, graduate and genetic counseling students on molecular diagnostics and its relationships to patient care, basic research, and ethical/legal/social implications.
  • Elective rotation experiences from several hours to several months to introduce medical students to clinical molecular diagnostics and projects in the laboratory

Training

  • Core Pathology Residency Program rotation in Molecular Diagnostics for residents in AP, AP/CP and CP-only training tracks
    • Emphasis on background molecular biology, molecular techniques, interpretation and reporting of assay data, professional consultation with clinical users, relevant topics in laboratory management
  • ACGME-accredited Molecular Genetic Pathology Fellowship Program
    • 3 fellows annually ('Standard' and 'MAP-intensive' training tracks)
    • Emphasis on depth and breadth of clinical expertise with junior attending-level responsibility sufficient to prepare trainees for Laboratory Director roles
  • ABMG-accredited Clinical Molecular Genetics Program
  • Occasional Visiting Scholars from other countries
  • Hematopathology Fellows – training in molecular hematopathology methods
  • Medical Genetics Residents – orientation to the Molecular Diagnostics Laboratory
  • Medical Students - Laboratory Medicine regular and longitudinal electives

CLIA, PA Department of Health, and CAP Certificates

If you have any questions about any of the information on this website,
please contact the Division of Molecular Diagnostics at 412-648-8519 or by email at mdx@upmc.edu.