Division of Gynecologic and Breast Cancer Pathology

Housed in Magee-Womens Hospital, the Division specializes in perinatal, obstetrical, neonatal, and gynecological pathology and cytopathology and performs all related diagnostic, teaching, and research activities for UPMC.

Faculty

Clinical Services

The Division serves as the diagnostic resource for the UPMC Health System as well as for others in our region and beyond. We perform all of the diagnostic services for gynecologic, breast, and gynecologic cytopathology specimens for patients throughout the UPMC Health System. In addition, the division has a very active consultation service. Diagnostic tools at our disposal are unparalled, and include immunohistology, fluorescence in situ hybridization (FISH), cytogenetics, and access to the molecular pathology laboratory of the department and the genomics facility.

Research Activities

The Division emphasizes several major areas of investigation. In the area of breast pathology, current ongoing basic research focuses on precursors of breast neoplasia, their immunohistologic detection and distinction from benign changes. Diagnostic immunohistochemistry of breast is an on-going study in which development of multiplex immunohistologic assays aid in diagnostic interpretation of breast risk lesions. Predictive/prognostic immunohistochemistry of breast is also an ongoing study area, aimed at optimizing tissue routing and fixation procedures for an ever-growing battery of predictive/prognostic markers. In gynecologic pathology, current focus is on the pathways of endometrioid neoplasia in the ovary, with atypical endometriotic lesions as the soil for neoplasia. Molecular abnormalities of these lesions are being studied, along with ARID 1A mutations. In cervical pathology, HPV models of risk have been developed using Pap test, HPV testing and patient demographics.

Educational Programs

Resident Rotation: The core Magee Pathology rotation of approximately 12 weeks offers the resident an introduction to the many facets of this complex field. The resident will begin to become familiar with the multiparameter approach to gynecologic and breast pathology and gynecologic cytopathology. The department is complemented by three full-time fellows in breast/gynegologic pathology. Core Resident Rotation Curriculum:
  • Breast pathology (~6 weeks)
  • Gynecologic pathology Hematology (~6 weeks)
  • Gynecologic cytopathology (~4 weeks, separate cytology rotation)
The Division also has an ACGME accredited selective fellowship program in breast / gynecologic pathology.

The Anisa I. Kanbour School of Cytotechnology and the School of Histotechnology both reside at Magee pathology. These schools provide cytotechnologists and histotechnologists for the UPMC Health System.