Hematopathology Center of Excellence

Wright-Giemsa 10x hemodilute bone marrow aspirate slide

Faculty

Mission Statement

The Division of Hematopathology, based at UPMC Presbyterian, has a broad and varied agenda achieving the classic academic triad of service, education and research. The Division staff includes eight faculty members with varied areas of expertise, three fellows, and an administrative staff.

Service

Flow cytometry analysis
The Division serves as the Diagnostic Hematopathology resource for the UPMC Health System, as well as for others in our region and beyond. It is directly responsible for all the diagnostic hematopathology at UPMC Presbyterian, UPMC Shadyside and The Childrens Hospital of Pittsburgh. In addition to diagnostic lymph node/solid tissue and adult and pediatric bone marrow services, the Division supervises a large Flow Cytometry Laboratory, the general hematology laboratories located at UPMC Presbyterian, UPMC Shadyside, and Magee-Womens Hospital. The division has active Consultation Services, accepting both fresh specimens for full evaluation or for special studies as well as previously fixed specimens. We emphasize a multiparameter approach to hematopathology that incorporates morphology, flow cytometric and paraffin section immunophenotypic data, genotypic data from the Division of Molecular Oncology and classical and molecular cytogenetic data from the Pittsburgh Cytogenetics Laboratory.

Education

The Division is active in medical student education including a senior elective in hematopathology. Much of our educational efforts are spent on resident education and on training our hematopathology fellows. Electives are also provided for clinical hematology/oncology fellows and other fellows in our department. More senior visitors are also welcome. Divisional members are also involved in a variety of national/international teaching activities.

Research

The Division emphasizes several major areas of investigation. Current ongoing basic research focuses on the roles of cell signaling abnormalities in the development and progression of acute leukemia. A large area of ongoing investigations is the use of a multiparameter approach in the study of non-Hodgkin lymphomas, post-transplant lymphoproliferative disorders (PTLD) and myeloid neoplasms. Examples of some specific areas of interest include aggressive B-cell lymphomas, splenic B-cell lymphomas, cutaneous lymphomas, other extranodal lymphomas, the lymphoma microenvironment, B-cell PTLD, myelodysplastic syndromes, and myeloid neoplasms with a monocytic component. Techniques range from standard morphology to complex genotypic studies. Most recently, several investigations have included single nucleotide polymorphism studies. The role of flow cytometric studies in dealing with selected problems in diagnostic hematopathology is another specific area of interest as is the evaluation of new instrumentation in diagnostic hematology. The Division also provides support for studies undertaken by our clinical colleagues.