Zoltan Nagy Oltvai, MD
Dr. Oltvai is a staff pathologist in the Division of Clinical Microbiology. He is also a faculty member of the Interdisciplinary Biomedical Science Graduate Program, the Medical Scientist Training Program, the Cellular and Molecular Pathology Graduate Training Program, and the Joint CMU-Pitt PhD Program in Computational Biology.
Associate Professor of Pathology
Rm. S701 Scaife Hall
3550 Terrace St.
Pittsburgh, PA 15213
Office Telephone: 412-383-7408
Lab Telephone: 412-648-8519
- MD - Semmelweiss Medical University, Budapest
Clinical ExpertiseMolecular Diagnostics (hereditary diseases, infectious diseases, hematologic malignancies)
Biomedical research today is conducted largely in the context of an established paradigm that is fundamentally reductionist in nature. Yet, despite the enormous success of this approach, it is increasingly clear that discrete biological function and the astounding complexity of living systems cannot be understood by studying individual molecules. Instead, most biological characteristics arise from complex interactions among the cell's numerous molecular constituents. Thus, a key challenge for 21st century biology is to understand the structure and the dynamics of the complex intracellular web of interactions among the various types of molecules that contribute to the function and the physical entity of a living cell. Together with our collaborators, our laboratory focuses on the understanding of the system-level organization of cellular metabolism, and how environmental cues are processed through regulatory pathways leading to rearranged metabolic activities. In the long run, we are also interested in applying this knowledge to improved disease diagnosis and treatment.
CertificationsClinical Pathology, 1998 (The American Board of Pathology)
SpecialtiesMolecular Diagnostics, Pathology Informatics
Selected PublicationsView Dr. Oltvai's publications on PubMed
- Tedeschi, P.M., Markert, E.K., Gounder, M., Lin, H., Dvorzhinski, D., Dolfi, S.C., Chan, L.L., Qiu, J., DiPaola, R.S., Hirshfield, K.M., Boros, L.G., Bertino, J.R., Oltvai, Z.N. and Vazquez, A. (2013) Contribution of serine, folate and glycine metabolism to the ATP, NADPH, and purine requirements of cancer cells. Cell Death Dis., 4, e877
- Dolfi, S.C., Chan, L.L., Qiu, J., Tedeschi, P.M., Bertino, J.R., Hirshfield K.M., Oltvai, Z.N. and Vazquez, A., (2013) The metabolic demands of cancer cells are coupled to their size and protein synthesis rates. Cancer & Metab.,1:20
- Cobanoglu, M.C., Liu, C., Hu, F., Oltvai, Z.N. and Bahar, I. (2013) Predicting drug-target interactions using probabilistic matrix factorization. J. Chem. Inf. Model. 53, 3399-409
- Zhou, Y., Vazquez, A., Wise, A., Warita, T., Warita, K., Bar-Joseph, Z., and Oltvai, Z.N. (2013) Carbon catabolite repression correlates with the maintenance of near invariant molecular crowding and optimal biomass production in proliferating E. coli cells. BMC Systems Biol. 7:138
- Liu, B., Bhatt, D., Oltvai, Z.N., Greenberger, J.S. and Bahar, I. (2014) Significance of p53 dynamics in regulating apoptosis in response to ionizing radiation, and polypharmacological strategies. Sci. Rep., 4: 6245
- Warita, K., Warita, T., Beckwitt, C., Schurdak, M.E., Vazquez, A., Wells, A. and Oltvai, Z.N., (2014) Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. Sci. Rep., 4:7593
- Cobanoglu, M.C., Oltvai, Z.N., Taylor, D.L. and Bahar, I. (2015) BalestraWeb: efficient, online evaluation of drug-target interactions. Bioinformatics, 31:131-133