Samuel A. Yousem, MD
Dr. Yousem is the Vice Chairman of Anatomic Pathology Services at UPMC, Director of the
Division of Anatomic Pathology, and Co-Director of the Community Pathology Division.
E. Leon Barnes Professor of Anatomic Pathology
Department of Pathology A610
200 Lothrop Street
Pittsburgh, PA 15213-2582
Office Telephone: 412-647-6193
- BS - 1977, Duke University
- MD - 1981, University of Maryland School of Medicine
Clinical ExpertiseDr. Yousem is a general surgical pathologist who has devoted the last ten years of his practice to focus on thoracic pathology. This expertise extends from inflammatory to neoplastic thoracic pathology. Perhaps his greatest impact has been in the area of pulmonary allograft pathology where Dr. Yousem, working at Stanford University and The University of Pittsburgh defined the histopathology of pulmonary allograft rejection and its variations and has been responsible for the three major revisions of international standards creating a working formulation for the standardization of nomenclature in the diagnosis of lung rejection. This effort most recently has focused on defining criteria for antibody mediated rejection in the lung allograft. At the same time Dr. Yousem has a great interest in chronic fibrosing interstitial lung disease, and has written extensively on the pathology of usual interstitial pneumonia, nonspecific interstitial pneumonia, respiratory bronchiolitis, smoking induced interstitial fibrosis, and pulmonary vasculitis.
In recent years, working with his colleague Sanja Dacic, MD PhD, his academic focus has been on the specific molecular drivers of pulmonary neoplasia, their association with specific histopathologies, and the prediction of biologic behavior based on molecular and histopathologic alterations. This interest has extended to a wide variety of unusual pulmonary malignancies, where the molecular pathology has in large part been defined by our molecular thoracic group, including studies of bronchioalveolar carcinoma/adenocarcinoma in situ, atypical adenomatous hyperplasia, sclerosing hemangioma of lung, chemodectomas, Langerhans cell histiocytosis, adenosquamous carcinoma and micropapillary adenocarcinoma. Dr. Yousem leads one of the most academically productive and internationally recognized sections in thoracic pathology in the world and as a result, he was recently presented with an endowed chair, the E. Leon Barnes Professor of Anatomic Pathology.
Research InterestsAs indicated above, Dr. Yousem has focused his energies on three areas of pathology: inflammatory lung disease, pathology of lung allografts, and the molecular alterations in pulmonary neoplasia. In each of these areas he is certainly regarded as one of the world leaders in correlating special studies including immunohistochemistry, fluorescence in situ hybridization, and molecular techniques with histopathology in an attempt to expand the differential diagnosis, prognostic importance, and pathobiology of thoracic inflammatory and neoplastic disease. Most recently, he has worked to re-define the spectrum of lung injury associated with cigarette smoking, e.g. smoking induced fibrosis, and on anti-synthetase syndrome associated lung disease.
CertificationsAnatomic Pathology: Cytopathology
Awards and HonorsLeon Barnes Professor of Surgical Pathology, 2012 - endowed chair
Selected PublicationsView Dr. Yousem's publications on PubMed
- Berry GJ, Burke M, Anderson K, Angelini A, Bruneval P, Calabrese F, Fishbein MC, Goddard M, Leone O, Maleszewski J, Marboe CM, Miller D, Neil D, Padera R, Raddi D, Revelo M, Rice A, Stewart S, Yousem SA. The Pathology of Pulmonary Antibody Mediated Rejection: 2012 Update from the Pathology Council of ISHLT. J Heart Lung Transplant 32:14-21, 2013.
- Roy S, Parwani AV, Dhir R, Yousem SA, Kelly SM, Pantanowitz L. Is There Discordance Between What Pathologist Say and What Surgeons Hear? AJCP 140:363-369, 2013.
- Yousem SA, Dacic S, Nikiforov YE, Nikiforova M. Pulmonary Langerhans Cell Histiocytosis. Profiling of Multifocal Tumors Using Next-Generation Sequencing Identifies Concordant Occurrence of BRAF V600E Mutations. Chest. 143(6):1679-84, 2013.
- Yousem SA, Lale S, Dacic S. HepPar-1 Expression in Primary Lung Adenocarcinoma. Am J Clin Pathol 140:225-230, 2013.
- Hartman, Douglas; Kelly, Susan; Wiehagen, Luke; Yousem, Samuel. Tissue Adequacy for Ancillary Studies Beyond Section: A Potential Method for Improving Diagnostic and Therapeutic Result. Int J Surg Path. 21(6):583-86, 2013.
- Luvison A, Sherer C, Yousem SA. Pulmonary Meningothelial-like Nodules are of Donor Origin in Lung Allografts. J Heart Lung Transpl 32(9):932-34, 2013.
- Yousem SA. Immunohistochemical and Molecular Characterization of Clear Cell Carcinoma of the lung. Human Path 44(11):2467-74, 2013.
- Yousem SA, Sherer C, Fuhrer K, Cieply K. Myofibroblasts of recipient origin are not the predominant mesenchymal cell in bronchiolitis obliterans in lung allografts. J Heart Lung Transplant. Feb;32(2):266-8, 2013.
- Hartman DJ, Parwani AV , Cable W, Cucoranu IC, McHugh JS, Kolowitz BJ, Yousem SA, Vijaykumar P, Von Reden A, Sloka S, Romero Lauro G, Ahmed I, Pantanowitz L. Pocket pathologist: a mobile application for rapid diagnostic surgical pathology consultation. J Pathol Inform 5:10, 2014.
- Yousem SA, Schneider F, Bi D, et al. The pulmonary histopathologic manifestations of the anti-PL7/antithreonyl transfer RNA synthetase syndrome. Human Pathology 45(6):1199-204, 2014.
- Roy S, Pantanowitz L, Amin M, Seethala RR, Ishtiaque A, Yousem SA, Parwani AV, Cucoranu I, Hartman DJ Smartphone adapters for digital photomicrography. J Pathol Inform Jul 30; 5:24, 2014.
- Comprehensive molecular profiling of lung adenocarcinoma. Cancer Genome Atlas Research Network. Nature, July 31;511:543-50. Epub 2014 Jul 9.
- George MP, Novelli EM, Shigemura N, Simon MA, Feingold B, Krishnamurti L, Morrell MR, Gries CG, Haider S, Johnson BA, Crespo MM, Bhama JK, Bermudez C, Toyoda Y, Champion HC, Pilewski JM, Gladwin MT. First successful lung transplantation for sickle cell disease with severe pulmonary arterial hypertension and pulmonary veno-occlusive disease. Pulm Circ 3(4):952-8, 2013.
- Schneider F, Yousem SA, Bi D, Gibson KR, Oddis CV, Aggarwal R. Pulmonary pathologic manifestations of anti-glycyl-tRNA synthetase (anti-EJ)-related inflammatory myopathy. J Clin Pathol 56(8):678-83, 2014.
- Schneider F, Aggarwal R, Bi D, Gibson K, Oddis C, Yousem SA. The pulmonary histopathology of anti-KS transfer RNA synthetase syndrome. Arch Pathol Lab Med.;139 (1):122-5. 2015.