Miguel Reyes-Múgica, MD
Marjory K. Harmer Endowed Chair in Pediatric Pathology
Dr. Reyes-Múgica is the Chief of the Division of Pediatric Pathology.
Department of Pathology
Children's Hospital of Pittsburgh
One Children's Hospital Drive
4401 Penn Avenue
Pittsburgh PA 15224
Office Telephone: 412-692-5650
Michelle Vinski - Administrative Coordinator
- MD - National Autonomous University of Mexico (UNAM), México City, México, 1982
Research InterestsFor many years, I have been involved in studies of childhood tumors and defects of neural crest cell migration. More recently, our lab has concentrated in the study of a neural crest disorders involving melanocytic proliferations, especially a disorder called neurocutaneous melanocytosis. Patients with this condition are born with large pigmented nevi (moles) and later develop meningeal/brain melanocytic proliferations. We are investigating the role of Epithelial-Mesenchymal Transition in the development of these abnormal proliferations. In addition, as a member of the Scientific Advisory Board of Nevus Outreach, Inc., a Pathology Consultation service for conditions related to Giant Melanocytic Nevi and Neurocutaneous Melanocytosis is offered.
Another condition within our diagnostic interests is Hirschsprung disease (congenital megacolon), in which neural crest-derived ganglion cells are not present in the colonic nervous system, leading to chronic constipation.
Other avenues of research interest include the early pathology of cancer predisposition syndromes. We are interested in seemingly trivial lesions that may foretell an increased cancer predisposition in the pediatric patient.
In addition, the pathology of pediatric testicular lesions, including Disorders of Sex Development is a current focus of our efforts. We collaborate with our colleagues in Pediatric Endocrinology, Pediatric Urological Surgery, Genetics, and others, to support a Clinic on these disorders. We also have collaborations with other institutions to develop new diagnostic approaches to these conditions. A Consultation service for Testicular Pediatric Pathology is offered.
- Pediatric and Developmental Pathology, Editor-in-Chief
- Society for Pediatric Pathology
- United States and Canadian Academy of Pathology
- Asociación Mexicana de Patólogos
- Sociedad Latinoamericana de Patologia Pediatrica (SLAPPE)
- Sociedad Latinoamericana de Patologia (SLAP)
- College of American Pathologists
- Latin American Pathology Foundation, Ex-President
Selected PublicationsView Dr. Reyes-Múgica's publications on PubMed
Odaib AL, Shneider BL, Bennett MJ, Pober BN, Reyes-Múgica M, Friedman AL, Suchy FJ, Rinaldo P. A defect of Long-chain fatty acid transport in a patient with recurrent fulminant liver failure. N Engl J Med 339:1752-1757,1998
Reyes-Múgica M, Meyerhardt J, Brierley KL, Jessica Rzasa, Rimm DL, Johnson KR, Wheelock MJ, Reale MA. Truncated DCC reduces N-caherin mediated adhesion in neuroblastoma cells. Lab Invest 80:201-210, 2001
Zambrano E, Reyes-Múgica M, Franchi A, Rosai J. Soft tissue-type clear cell sarcoma of the bowel: a gist simulator. Int J Surg Pathol 2003 Apr;11(2):75-81
Cheng E, Trombetta SE, Kovacs D, Beech RD, Ariyan S, Reyes-Múgica M, McNiff JM, Narayan D, Kluger HM, Picardo M, Halaban R. Rab33A: Characterization, Expression, and Suppression by Epigenetic Modification. J Invest Dermatol. 2006 Jun 29; [Epub ahead of print] PMID: 16810302.
Cajaiba MM, Bale A , Alvarez-Franco M, Reyes-Múgica M. Rhabdomyosarcoma, Wilms Tumor, and Deletion of the patched gene in Gorlin Syndrome. Nature Clinical Practice Oncology 2006 Oct; 3(10):575-580
Gwin K, Cajaiba MM, Caminoa-Lizarralde A, Picazo ML, Nistal M, Reyes-Múgica M. Expanding the Clinical Spectrum of Frasier Syndrome. Pediatr Dev Pathol 2008 Mar-Apr;11(2):122-7
Cajaiba MM, Benjamin D, Halaban R, Reyes-Múgica M. Metastatic Peritoneal Neurocutaneous Melanocytosis. Am J Surg Pathol 2008 Jan; 32:156-161
Picarsic J, Jaffe R, Mazariegos G, Webber S, Ellis D, Green M, Reyes-Múgica M. Post-transplant Burkitt Lymphoma is a more aggressive and distinct form of PTLD. Cancer 2011 Mar 28. doi: 10.1002/cncr.26001
Salgado C M, Silver RB, Bauer BS, Basu D, Schmitt L, Khakoo Y, Reyes-Múgica M. Skin Of Patients With Large/Giant Congenital Melanocytic Nevi Shows Increased Mast Cells. Pediatr Dev Pathol 2014 May-Jun;17(3):198-203. doi: 10.2350/14-02-1444-OA.1
Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 1. Normal Development of Testicular Structures: From The Bipotential Gonad To The Fetal Testis. Pediatr Dev Pathol 2014 Aug 13. [Epub ahead of print]
Picarsic J, Reyes-Múgica M. Phenotype And Immunophenotype Of The Most Common Pediatric Tumors. Appl Immunohistochem Mol Morphol . 2014 Nov 11. [Epub ahead of print]
Salgado CM, Basu D, Nikiforova M, Bauer BS, Johnson D, Rundell V, Grunwaldt LJ, Reyes-Múgica M. BRAF Mutations Are Also Associated With Neurocutaneous Melanocytosis and Large/Giant Congenital Melanocytic Nevi. Pediatr Dev Pathol 20 2015 Jan-Feb;18(1):1-9.