Miguel Reyes-Múgica, MD
Professor of Pathology

Miguel Reyes-Múgica, MD
Dr. Reyes-Múgica is the Chief of the Division of Pediatric Pathology.
Office Location:
Department of Pathology
Children's Hosptial of Pittsburgh
One Children's Hospital Drive
4401 Penn Avenue
Pittsburgh PA 15224
Contact Information:
Office Telephone: 412-692-5650
Fax: 412-692-6550
Email: miguel.reyes@chp.edu


  • MD - National Autonomous University of Mexico (UNAM), México City, México, 1982

Research Interests

For many years, I have been involved in studies of childhood tumors and defects of neural crest cell migration. More recently, our lab has concentrated in the study of a neural crest disorders involving melanocytic proliferations, especially a disorder called neurocutaneous melanocytosis. Patients with this condition are born with large pigmented nevi (moles) and later develop meningeal/brain melanocytic proliferations. We are investigating the role of Epithelial-Mesenchymal Transition in the development of these abnormal proliferations. In addition, as a member of the Scientific Advisory Board of Nevus Outreach, Inc., a Pathology Consultation service for conditions related to Giant Melanocytic Nevi and Neurocutaneous Melanocytosis is offered.

Another condition within our diagnostic interests is Hirschsprung disease (congenital megacolon), in which neural crest-derived ganglion cells are not present in the colonic nervous system, leading to chronic constipation.

Other avenues of research interest include the early pathology of cancer predisposition syndromes. We are interested in seemingly trivial lesions that may foretell an increased cancer predisposition in the pediatric patient.

In addition, the pathology of pediatric testicular lesions, including Disorders of Sex Development is a current focus of our efforts. We collaborate with our colleagues in Pediatric Endocrinology, Pediatric Urological Surgery, Genetics, and others, to support a Clinic on these disorders. We also have collaborations with other institutions to develop new diagnostic approaches to these conditions. A Consultation service for Testicular Pediatric Pathology is offered.


  • Pediatric and Developmental Pathology, Editor-in-Chief
  • Society for Pediatric Pathology
  • United States and Canadian Academy of Pathology
  • Asociación Mexicana de Patólogos
  • Sociedad Latinoamericana de Patologia Pediatrica (SLAPPE)
  • Sociedad Latinoamericana de Patologia (SLAP)
  • Histiocyte Society
  • College of American Pathologists
  • Latin American Pathology Foundation, Ex-President
  • Southern CT Pathology Society

Selected Publications

View Dr. Reyes-Múgica's publications on PubMed

Odaib AL, Shneider BL, Bennett MJ, Pober BN, Reyes-Múgica M, Friedman AL, Suchy FJ, Rinaldo P. A defect of Long-chain fatty acid transport in a patient with recurrent fulminant liver failure. N Engl J Med 339:1752-1757,1998

Reyes-Múgica M, Meyerhardt J, Brierley KL, Jessica Rzasa, Rimm DL, Johnson KR, Wheelock MJ, Reale MA. Truncated DCC reduces N-caherin mediated adhesion in neuroblastoma cells. Lab Invest 80:201-210, 2001

Zambrano E, Reyes-Múgica M, Franchi A, Rosai J. Soft tissue-type clear cell sarcoma of the bowel: a gist simulator International J Surg Pathol 2003 Apr;11(2):75-81

Cajaiba MM, Bale A , Alvarez-Franco M, Reyes-Múgica M. Rhabdomyosarcoma, Wilms Tumor, and Deletion of the patched gene in Gorlin Syndrome. Nature Clinical Practice Oncology 2006 Oct; 3(10):575-580

Gwin K, Cajaiba MM, Caminoa-Lizarralde A, Picazo ML, Nistal M, Reyes-Múgica M. Expanding the Clinical Spectrum of Frasier Syndrome. Pediatr Dev Pathol 2008 Mar-Apr;11(2):122-7

Cajaiba MM, Benjamin D, Halaban R, Reyes-Múgica M. Metastatic Peritoneal Neurocutaneous Melanocytosis. Am J Surg Pathol 2008 Jan; 32:156-161

McElrath TF, Hecht JL, Dammann O, Boggess K, Onderdonk A, Markenson G, Harper M, Delpapa E, Allred EN, Leviton A and for the ELGAN Study Investigators (Reyes-Múgica M). Pregnancy disorders that lead to delivery before the 28th week of gestation: an epidemiologic approach to classification. Am J Epidemiol 2008 Nov 1;168(9):980-9

Picarsic J, Jaffe R, Mazariegos G, Webber S, Ellis D, Green M, Reyes-Múgica M. Post-transplant Burkitt Lymphoma is a more aggressive and distinct form of PTLD. Cancer 2011 Mar 28. doi: 10.1002/cncr.26001

Cheng E, Trombetta SE, Kovacs D, Beech RD, Ariyan S, Reyes-Múgica M, McNiff JM, Narayan D, Kluger HM, Picardo M, Halaban R. Rab33A: Characterization, Expression, and Suppression by Epigenetic Modification. J Invest Dermatol. 2006 Jun 29; [Epub ahead of print] PMID: 16810302.