Zoltan Nagy Oltvai, MD
Dr. Oltvai is a staff pathologist in the Division of Molecular Genomic Pathology and medical director of Specialty Lab Informatics. He is also a faculty member of the Interdisciplinary Biomedical Science Graduate Program, the Medical Scientist Training Program, the Cellular and Molecular Pathology Graduate Training Program, and the Joint CMU-Pitt PhD Program in Computational Biology.
Associate Professor of Pathology
Rm. S701 Scaife Hall
3550 Terrace St.
Pittsburgh, PA 15213
Office Telephone: 412-383-7408
Lab Telephone: 412-648-8519
- MD - Semmelweiss Medical University, Budapest
Clinical ExpertiseMolecular Diagnostics (hereditary diseases, infectious diseases, hematologic malignancies)
Research InterestsDr. Oltvai's research interest is in the area of systems biology of cell metabolism, including the metabolism of prokaryotic and mammalian cells, including tumor cells.
CertificationsClinical Pathology, 1998 (The American Board of Pathology)
SpecialtiesMolecular Diagnostics, Pathology Informatics
Selected PublicationsView Dr. Oltvai's publications on PubMed
Shen, Y., Liu, J., Estiu, G., Isin, B., Ahn, Y-Y., Lee, D-S., Barabasi, A.-L., Kapatral, V., Wiest, O., and Oltvai, Z.N., Blueprint for antimicrobial hit discovery targeting metabolic networks. Proc. Natl. Acad. Sci. U.S.A. 107, 1082-87 (2010)
Vazquez, A., Liu, J., Zhou, Y., and Oltvai, Z.N. Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited. BMC Systems Biol., 4, 58 (2010)
Vazquez, A., and Oltvai, Z.N. Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology. PLoS ONE 6 (e19538), 1-9 (2011)
Vazquez, A., Markert, E.K., and Oltvai, Z.N. Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. PLoS ONE, 6 (e25881), 1-10 (2011)
Isin, B., Estiu, G., Wiest, O., and Oltvai, Z.N., (2012) Identifying ligand binding conformations of the ?2-adrenergic receptor by using its agonists as computational probes. PLoS ONE, 7 (e50186), 1-12
Tedeschi, P.M., Markert, E.K., Gounder, M., Lin, H., Dvorzhinski, D., Dolfi, S.C., Chan, L.L., Qiu, J., DiPaola, R.S., Hirshfield, K.M., Boros, L.G., Bertino, J.R., Oltvai, Z.N. and Vazquez, A. (2013) Contribution of serine, folate and glycine metabolism to the ATP, NADPH, and purine requirements of cancer cells. Cell Death Dis., 4, e877
Dolfi, S.C., Chan, L.L., Qiu, J., Tedeschi, P.M., Bertino, J.R., Hirshfield K.M., Oltvai, Z.N. and Vazquez, A., (2013) The metabolic demands of cancer cells are coupled to their size and protein synthesis rates. Cancer & Metab.,1:20
Zhou, Y., Vazquez, A., Wise, A., Warita, T., Warita, K., Bar-Joseph, Z., and Oltvai, Z.N. (2013) Carbon catabolite repression correlates with the maintenance of near invariant molecular crowding and optimal biomass production in proliferating E. coli cells. BMC Systems Biol. 7:138