Mona F. Melhem, MD
Professor of Pathology

Dr. Melham
Dr. Melhem is the Associate Chief of Staff and Vice President of Clinical Support Service Line at the Veterans Affairs Pittsburgh Healthcare System (VAPHS). She is the Director of Pathology and Laboratory Medicine.

Office Location:
11 E 128, VAPHS
Veterans' Affairs Medical Center
University Drive C
Pittsburgh, PA 15240
Contact Information:
Office Telephone: 412-360-6745
Fax: 412-360-6135


American Board of Pathology: Anatomic Pathology, Clinical Pathology, Hematopathology

Clinical Expertise: Hematopathology and Renal Pathology

Research Interests

Dr. Melhem's interests are differential expression of oncogenes in hematopoietic and non-hematopoietic cancer development using molecular, laser-captured microscopy, histochemical, immunohistochemical, and image analysis methods. Dr. Melhem also directs the Tumor Banking and The Pathology Laboratory for research support labs at the VAPHS.

Selected Publications

View Dr. Melhem's publications on PubMed

  • Gao W, Mady HH, Melhem MF, Keohavong P.Analysis of p53 mutations in histologically normal lung tissues and lung tumors from non-small cell lung cancer patients. Mol Carcinog. 2009 Jul;48(7):633-41. PMID: 19072763 [PubMed - indexed for MEDLINE]
  • Oton AB, Wang H, Leleu X, Melhem MF, George D, Lacasce A, Foon K, Ghobrial IM. Clinical and pathological prognostic markers for survival in adult patients with post-transplant lymphoproliferative disorders in solid transplant. Leuk Lymphoma. 2008 Sep;49(9):1738-44. PMID: 18798108 [PubMed - indexed for MEDLINE] .
  • Alsayed Y, Leleu X, Leontovich A, Oton AB, Melhem M, George D, Ghobrial IM. Proteomics analysis in post-transplant lymphoproliferative disorders. Eur J Haematol. 2008 Oct;81(4):298-303. Epub 2008 Jul 28.
  • DeRubertis FR, Craven PA, Melhem MF. Acceleration of diabetic renal injury in the superoxide dismutase knockout mouse: effects of tempol. Metabolism. 2007 Sep;56(9):1256-64. PMID: 17697870 [PubMed - indexed for MEDLINE]
  • Florea AV, Ionescu DN, Melhem MF. Parvovirus B19 infection in the immunocompromised host. Arch Pathol Lab Med. 2007 May;131(5):799-804. Review. PMID: 17488170 [PubMed - indexed for MEDLINE]
  • Jackson TC, Mi Z, Bastacky SI, McHale T, Melhem MF, Sonalker PA, Tofovic SP, Jackson EK. PPAR alpha agonists improve renal preservation in kidneys subjected to chronic in vitro perfusion: interaction with mannitol. Transpl Int. 2007 Mar;20(3):277-90. PMID: 17291221 [PubMed - indexed for MEDLINE]
  • Tofovic SP, Salah EM, Jackson EK, Melhem M. Early renal injury induced by caffeine consumption in obese, diabetic ZSF1 rats. Ren Fail. 2007;29(7):891-902. PMID: 17994459 [PubMed - indexed for MEDLINE]
  • Hatjiharissi E, Ngo H, Leontovich AA, Leleu X, Timm M, Melhem M, George D, Lu G, Ghobrial J, Alsayed Y, Zeismer S, Cabanela M, Nehme A, Jia X, Moreau AS, Treon SP, Fonseca R, Gertz MA, Anderson KC, Witzig TE, Ghobrial IM. Proteomic analysis of waldenstrom macroglobulinemia. Cancer Res. 2007 Apr 15;67(8):3777-84. PMID: 17440091 [PubMed - indexed for MEDLINE]