Youhua Liu, PhD
Professor of Pathology
Dr. Liu is a member of the Division of Experimental Pathology and a member of the Cellular and Molecular Pathology Graduate Training Program.
200 Lothrop St.
Pittsburgh, PA 15261
Office Telephone: 412-648-8253
Lab Telephone: 412-648-9508
- BS - 1982, Anhui University
- PhD - 1998, Peking Union Medical College
Research InterestsStudies in Dr. Liu's laboratory are focused on dissecting the cellular and molecular pathways leading to chronic renal fibrosis, and exploring novel strategies for therapeutic interventions. Using a series of experimental approaches, we are addressing several fundamental issues in renal fibrosis, such as what types of cells produce a large amount of matrix proteins under pathologic conditions and how they are regulated. Current studies in our laboratory include: 1) to decipher the mechanisms controlling tubular epithelial-mesenchymal transition (EMT) and epithelial-mesenchymal cross-talks (EMC) in renal fibrogenesis; 2) to dissect several key signal pathways such as Wnt/beta-catenin, hedgehog and integrin-linked kinase in the pathogenesis of renal fibrosis; 3) to elucidate the patho-mechanisms of podocyte injury and proteinuria; 4) to develop novel therapeutic strategies aimed at ameliorating renal fibrosis and kidney dysfunction.
NIH ResearchView Dr. Liu's NIH RePORT on nih.gov
Selected PublicationsView Dr. Liu's publications on PubMed
- Zhou L, Li Y, Zhou D, Tan RJ, and Liu Y. 2013. Loss of klotho contributes to kidney injury by derepression of Wnt/β-catenin signaling. J. Am. Soc. Nephrol. 24: 771-785. (Featured on JASN cover; and Editorial: Klotho to treat kidney fibrosis. JASN 24: 687-689, 2013; Featured on Faculty of 1000 Prime, doi: 10.3410/f.717997088.793478199).
- Zhou D, Tan RJ, Lin L, Zhou L, and Liu Y. 2013. Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury. Kidney Int. 84: 509-520.
- Zhou D, Tan RJ, Zhou L, Li Y, and Liu Y. 2013. Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication. Sci. Rep. 3, 1878; doi: 10.1038/srep01878.
- Cheng A, Dong Y, Zhu F, Liu Y, Hou FF, and Nie J. 2013. AGE-LDL activates Toll Like receptor 4 pathway and promotes inflammatory cytokines production in renal tubular epithelial cells. Int. J. Biol. Sci. 9: 94-107.
- Wei X, Xia Y, Li F, Tang Y, Nie J, Liu Y, Zhou Z, Zhang H, Hou FF. 2013. Kindlin-2 mediates activation of TGF-β/Smads signaling and renal fibrosis. J. Am. Soc. Nephrol. 24: 1387-1398. (Featured on Editorial: Hirschberg R. Kindlin-2: A new player in renal fibrogenesis. JASN 24: 1339-1340, 2013).
- Tan RJ, Zhou L, Zhou D, Lin L, and Liu Y. 2013. Endothelin Receptor A blockade is an ineffective treatment for adriamycin nephropathy. PLoS One. 8: e79963.
- Tan RJ, and Liu Y. 2013. Macrophage-derived TGF-β in renal fibrosis: not a macro-impact after all. Am. J. Physiol. Renal Physiol. 305: F821-F822.
- Xiao L, and Liu Y. 2013. Chronic Kidney Disease: Fibrosis and anemia in CKD -- two beasts, one ancestor. Nat. Rev. Nephrol. 9: 563-565.
- Tan RJ, and Liu Y. 2014. Arrestin(g) podocyte injury with endothelin antagonism. J. Am. Soc. Nephrol. 25: 423-425.
- Tan RJ, Zhou D, Zhou L, and Liu Y. 2014. Wnt/β-catenin signaling and kidney fibrosis. Kidney Int. Supple 4: 84-90.
- Zhou D, Li Y, Zhou L, Tan RJ, Xiao L, Liang M, Hou FF, and Liu Y. 2014. Sonic hedgehog is a novel tubule-derived growth factor for interstitial fibroblasts after kidney injury. J. Am. Soc. Nephrol. 25: 2187-2200. Featured on JASN cover
- Chu GCY, Zhau HE, Wang R, Rogatko A, Feng X, Zayzafoon M, Liu Y, Farach-Carson MC, You S, Kiam J, Freeman MR, Chung LWK. 2014. RANK- and c-Met-mediated signal network amplification promotes prostate cancer metastatic colonization. Endocr-Relat Cancer. 21: 311-326
- Wang J, Liang M, Xu J, Cao W, Wang GB, Zhou ZM, Tian JW, Jia N, Zhang ZH, Nie J, Liu Y, Hou FF. 2014. Renal expression of advanced oxidative protein products predicts progression of renal fibrosis in patients with IgA nephropathy. Lab. Invest. 94: 966-977.
- Pawaria S, Ramani K, Maers K, Liu Y, Kane LP, Levesque MC, Biswas PS. 2014. Complement component C5a permits the coexistence of pathogenic Th17 cells and type I IFN in Lupus. J. Immunol. 193: 3288-3295.
- Guan X, Nie L, Yang K, Huang Y, He T, Zhang J, Xiao T, Sharma K, Liu Y, Zhao J. 2014. Klotho suppresses renal tubulointerstitial fibrosis by controlling basic fibroblast growth factor-2 signaling. J. Pathol. 234: 560-572.
- Zhou L, Li Y, Hao S, Zhou D, Tan RJ, Nie J, Hou FF, Kahn M, and Liu Y. 2015. Multiple genes of the renin-angiotensin system are novel targets of Wnt/β-catenin signaling. J. Am. Soc. Nephrol. 26: 107-120. Featured on Editorial: Floege J. Antagonism of canonical Wnt/β-catenin signaling: Taking RAS blockade to the next level? J. Am. Soc. Nephrol. 26: 3-5, 2015. Highlighted on Nat. Rev. Nephrol. News story: Targeting multiple RAS genes. By Carney EF. Nat. Rev. Nephrol 10: 482, 2014.
- Zhou L, Li Y, He W, Zhou D, Tan RJ, Nie J, Hou FF, and Liu Y. 2015. Mutual antagonism of Wilms' tumor 1 and β-catenin dictates podocyte health and disease. J. Am. Soc. Nephrol. 26: 677-691.
- An J, Nie J, He J, Guo Q, Li M, Lei Y, Liu Y, Zhou Z, Zhu F, Liang M, Cheng Y, Hou FF. 2015. GQ5 hinders renal fibrosis in obstructive nephropathy by selectively inhibiting TGF-β-induced Smad3 phosphorylation. J. Am. Soc. Nephrol. 26: 000-000, in press.
- Tan RJ, Zhou D, Xiao L, Zhou L, Li Y, Bastacky SI, Oury TD, and Liu Y. 2015. Extracellular SOD protects against proteinuric kidney disease. J. Am. Soc. Nephrol. 26: 000-000, in press.
- Fu H, and Liu Y. 2015. Loss of Klotho in CKD breaks one's heart. J. Am. Soc. Nephrol. 26: 000-000.
- Zhou L, and Liu Y. 2015. Wnt/β-catenin signaling and podocyte dysfunction in proteinuric kidney disease. Nat. Rev. Nephrol. 0: 000-000, in press.