Eric Lagasse, PharmD, PhD
Associate Professor of Pathology

Dr. Lagasse
Dr. Lagasse is a member of the Division of Experimental Pathology and the McGowan Institute for Regenerative Medicine.
Office Location:
McGowan Institute for Regenerative Medicine
University of Pittsburgh
450 Technology Drive
Pittsburgh, PA 15219
Contact Information:
Office Telephone: 412-624-5285
Lab Telephone: 412-624-5290
Fax: 412-624-5363
Email: lagasse@pitt.edu

Education

  • PharmD - 1985, Louis Pasteur University, Strasbourg, France
  • PhD - 1989, University of Basel, Switzerland

Research Interests

My research is focused primarily on stem cell biology and cell-based therapy for a variety of diseases including cancer. Specific areas of interest comprise cell-based therapy for liver disease, ectopic organogenesis, bioartificial tumors development and identification of normal and cancer stem cells.

Recent Publications (2008-2011)

View Dr. Lagasse's publications on PubMed.

Manohar, R., Komori J., Guzik L., Stolz D. Chandran U.R. LaFramboise W.A. and Lagasse E. (2011). Identification and Expansion of a Unique Stem Cell Population from Adult Mouse Gallbladder. Hepatology. 54:1830-41.

Soto-Gutierrez A., Zhang L., Medberry C., Fukumitsu K., Faulk D., Jiang H., Reing J., Gramignoli R., Komori J., Ross M., Nagaya M., Lagasse E., Stolz D., Strom S.C., Fox I.J., and Badylak S. (2011) A Whole Organ Regenerative Medicine Approach for Liver Replacement. Tissue Engineering Part C. Jun;17(6):677-86. PMID: 21375407.

Hoppo, T., Komori, J. Manohar R., Stolz D.B. and Lagasse E. (2011). Rescue of Lethal hepatic failure by hepatized lymph nodes in mice. Gastroenterology. 140 (2) 656-666.

Chandler J. and Lagasse E. (2010). Cancerous Stem Cells: Deviant Stem Cells with Cancer Causing Misbehavior. Stem Cell Research & Therapy. 1 (2): 13.

Manohar R. and Lagasse E. (2009). Transdetermination: a new trend in cellular reprogramming. Molecular Therapy. 17 (6): 936-938.

Teisanu, R.M., Lagasse E., Whitesides J. and Stripp B. R. (2008). Prospective Isolation of Bronchiolar Stem Cells. Stem Cells. 27(3):612-22.

Odoux C., Fohrer F., Hoppo T., Guzik T., Stolz D.B., Lewis D.W., Gollin S.M., Gamblin T.C., Geller D.A., and Lagasse E. (2008). A Stochastic Model for Cancer Stem Cell Origin. Cancer Research. 68: 6932-41.

Lagasse E. (2008). Cancer Stem Cells with Genetic Instability: The Best Vehicle with the Best Engine for Cancer. Gene Therapy. 15:136-142.

Xiong A., Austin W.T., Lagasse E., Uchida N., Tamaki S., Bordier B., Weissman I.L. Glenn JS and Millan M. Isolation of Human Fetal Liver Progenitors and their Enhanced Proliferation by 3-Dimensional Co-culture with Endothelial Cells. Tissue Eng. (2008). Part A. Apr 23.

Rajasekhar V. K., Dalerba P., Passegué E., Lagasse E., Najbauer J. Meeting report. The 5th International Society for Stem Cell Research (ISSCR) Annual Meeting, June 2007. Stem Cells. (2008). 26:292-298.