Frank J. Jenkins, PhD
Associate Professor of Pathology
Dr. Jenkins is a member of the University of Pittsburgh Cancer Institute.
HCCLB Rm G.17
5117 Centre Ave.
Pittsburgh, PA 15213
Office Telephone: 412-623-3233
Lab Telephone: 412-623-3234
- MS - 1979, University of North Texas
- PhD - 1984, Penn State School of Medicine
Research InterestsI have over 25 years experience as a molecular virologist studying human herpes viruses including pathogenesis, gene function and seroprevalence. Our laboratory is involved on several studies on human herpesvirus-8 including immune responses, establishment and reactivation of viral latency and gene function.
We have also been involved for several years in biobehavioral medicine. Specifically, we are interested in the role of stress and stress hormones in disease pathogenesis. Our current studies involve how stress hormones affect individual cells, the types of damage they may inflict on these cells and the outcomes of these interactions.
Selected PublicationsView Dr. Jenkins' publications on PubMed
Hensler, H.R., Rappocciolo, G.R., Rinaldo, C.R. and Jenkins, F.J. Cytokine production by human herpesvirus 8-infected dendritic cells. J. Gen. Virol. 90:79-83, 2009.
McDonald, A.C., Ragin, C.C., Jenkins, F.J., Weissfeld, J., Wilson, J., Wheeler, V.W., Wilson, J.B., Bunker, C.H. and Taioli, E. Human Herpesvirus 8 seroprevalence among Tobago women and the role of sexual lifestyle behavior. J. Med. Virol. 81:264-70.
Chao C, Jacobson LP, Jenkins FJ, Tashkin D, Martínez-Maza O, Roth MD, Ng L, Margolick JB, Chmiel JS, Zhang ZF, Detels R. 2009. Recreational drug use and risk of Kaposi's sarcoma in HIV- and HHV-8-coinfected homosexual men. AIDS Res Hum Retroviruses. 25:149-56.
Tolstov, Y.L., Pastrana, D.V., Feng, H., Becker, J.C., Jenkins, F.J., Moschos, S., Chang, Y., Buck, C.B. and Moore, P.S. 2009 Human merkel cell polyomavirus infection II. 2009. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. Intern J Can. 125:1250-1256.
Sutcliffe S, Kawachi I, Alderete JF, Gaydos CA, Jacobson LP, Jenkins FJ, Viscidi RP, Zenilman JM, Platz EA. 2009. Correlates of sexually transmitted infection histories in a cohort of American male health professionals. Cancer Causes Control. 2009 20:1623- 34.
Lepone L, Rappocciolo G, Knowlton E, Jais M, Piazza P, Jenkins FJ, Rinaldo CR 2010.Monofunctional and polyfunctional CD8+ T cell responses to human herpesvirus 8 lytic and latency proteins. lin Vaccine Immunol. 17:1507-1516.
Carroll JE, Marsland AL, Jenkins F, Baum A, Muldoon MF, Manuck SB. 2010. A urinary marker of oxidative stress covaries positively with hostility among midlife community volunteers. Psychosomatic Medicine. 72:273-280.
Qu L, Jenkins F, Triulzi DJ 2010. Human herpesvirus 8 genomes and seroprevalence in United States blood donors. Transfusion. 50:1050-1056.
Qu L, Triulzi DJ, Rowe DT, Jenkins, FJ. 2011. Detection of HHV-8 (human herpesvirus-8) genomes in induced peripheral blood mononuclear cells (PBMCs) from US blood donors. Vox Sanguinis. 100:267-271.
Flint, M, McCarty, K, Jenkins, F, Condrads, T, Sun, M, Baum, A. 2011. Psychological stress accelerates the onset of tumour formation and alters the type and location of tumours in a DMBA mouse carcinogenesis model. Stress & Health 27:e129-e138.
McDonald AC, Jenkins FJ, Bunker CH, Wilson JW, Patrick AL, Weissfeld JL. 2011. A case-cohort study of human herpesvirus 8 seropositivity and incident prostate cancer in Tobago. Infect Agent Cancer. 2011 Dec 7;6(1):25. [Epub ahead of print] PMID:22151996
Flint, MS, Baum A, Episcopo B, Knickelbein KZ, Dougall AJL, Chambers WH, Jenkins FJ. 2012. Chronic exposure to stress hormones promote transformation and tumorigenicity of 3T3 mouse fibroblasts. Stress In press.