Frank J. Jenkins, PhD
Associate Professor of Pathology
Dr. Jenkins is a member of the University of Pittsburgh Cancer Institute.
HCCLB Rm G.17
5117 Centre Ave.
Pittsburgh, PA 15213
Office Telephone: 412-623-3233
Lab Telephone: 412-623-3234
- MS - 1979, University of North Texas
- PhD - 1984, Penn State School of Medicine
Research InterestsI have over 25 years experience as a molecular virologist studying human herpes viruses including pathogenesis, gene function and seroprevalence. Our laboratory is involved on several studies on human herpesvirus-8 including immune responses, establishment and reactivation of viral latency and gene function.
We have also been involved for several years in biobehavioral medicine. Specifically, we are interested in the role of stress and stress hormones in disease pathogenesis. Our current studies involve how stress hormones affect individual cells, the types of damage they may inflict on these cells and the outcomes of these interactions.
Selected PublicationsView Dr. Jenkins' publications on PubMed
Flint MS, Baum A, Episcopo B, Knickelbein KZ, Liegey Dougall AJ, Chambers WH, Jenkins FJ. 2012. Chronic exposure to stress hormones promotes transformation and tumorigenicity of 3T3 mouse fibroblasts. Stress 16:114-121, 2013.
Sutcliffe S, Till C, Gaydos CA, Jenkins FJ, Goodman PJ, Hoque AM, Hsing AW, Thompson IM, Zenilman JM, Nelson WG, DeMarzo AM, Platz EA. 2012. Prospective study of cytomegalovirus serostatus and prostate cancer risk in the Prostate Cancer Prevention Trial. Cancer Causes Control 23:1511-1518.
Knowlton ER, Lepone LM, Li J, Rappocciolo G, Jenkins FJ, Rinaldo CR. 2012. Professional antigen presenting cells in human herpesvirus 8 infection. Front. Immunol. 3:427. PMID: 23346088.
Nadgir, SV, Hensler, HR, Knowlton, ER, Rinaldo, CR, Rappocciolo G, Jenkins FJ. 2013. Fifty percent tissue culture infective dose assay for determining the titer of infectious human herpesvirus 8. J Clin Microbiol 51:1931-1934.
Knowlton, ER, Lepone, LM, Li, J, Rappocciolo G, Jenkins FJ, Rinaldo, CR. 2013. Professional antigen presenting cells in human herpesvirus 8 infection. Front Immunol 3:427.
Forero, A., McCormick, KD, Jenkins, FJ, & Sarkar, SN. 2014. Downregulation of IRF4 induces lytic reactivation of KSHV in primary effusion lymphoma cells. Virology, 458, 4-10.
Low, CA, Bovbjerg, DH, Jenkins, FJ, Ahrendt, SA, Choudry, HA, Holtzman, MP, Bartlett, DL. 2014. Preoperative inflammatory biomarkers and neurovegetative symptoms in peritoneal carcinomatosis patients. Brain, Behavior, and Immunity. 42:65- 68.
. Hensler, HR, Tomaszewski, MJ, Rappocciolo, G, Rinaldo, CR, & Jenkins, FJ. 2014. Human herpesvirus 8 glycoprotein B binds the entry receptor DC-SIGN. Virus Research, 190, 97-103.
Knowlton ER, Rappocciolo G, Lepone LM, Nagir S, Bullotta A, Berendam SJ, Piazza PA, Jenkins FJ, Rinaldo CR. 2014. Human Herpesvirus 8 Induces Polyfunctional B Lymphocytes that Drive Kaposi's Sarcoma. mBio, 5(5), e01277-14. doi: 10.1128/mBio.01277-14.
Campbell, DM, Rappocciolo, G, Jenkins, FJ, & Rinaldo, CR. 2014. Dendritic cells: Key players in human herpesvirus 8 infection and pathogenesis. Frontiers in Microbiology, 5:452. doi: 10.3389/fmicb.2014.00452.
Jenkins, FJ, Van Houten, B., & Bovbjerg, DH. 2014. Effects on DNA Damage and/or Repair Processes as Biological Mechanisms Linking Psychological Stress to Cancer Risk. Journal of Applied Biobehavioral Research, 19(1), 3-23.
Sutcliffe S, Till, C, Jenkins FJ, Gaydos CA, Goodman PJ, Hoque AM, Hsing AW, Thompson IM, Nelson WG, De Marzo AM, Platz EA. Prospective study of human herpesvirus type 8 serostatus and prostate cancer risk in the placebo arm of the Prostate Cancer Prevention Trial. Cancer Causes Control. 2015. 26:35-44. Doi: 10.1007/s10552- 014-0480-5.