Roy A. Frye, MD, PhD
Associate Professor of Pathology

Dr. Frye is a member of the Division of Pathology at the Veterans Affairs Pittsburgh Healthcare System (VAPHS).

Office Location:
Pittsburgh VA Medical Center
Pathology, 132L-U
University Drive C
Pittsburgh, PA 15240

Contact Information:
Office Telephone: 412-360-6550
Lab Telephone: 412-360-6449

Clinical Expertise

  • Liver biopsies - hepatic tumors, fatty liver disease, and transplant pathology
  • Prostate biopsies

Research Interests

  • Sirtuin genes and influence on energy metabolism and aging pathways
  • General mechanisms of aging, health, and longevity
  • Role of cognition in influencing health and longevity (especially in relation to susceptibility to cardiovascular disease, obesity/type2 diabetes, lung cancer, and emphysema)
  • Role of cognition and vagus nerve signaling in controlling systemic inflammation and health and longevity
  • Role of diet, particularly level of fructose consumption, in influencing susceptibility to fatty liver, obesity/type 2 diabetes, systemic inflammation, and cardiovascular disease

Selected Publications

View Dr. Frye's publications on PubMed

  • Frye, Roy. Cognitive epidemiology of ethnic health and the CHRM2 vagal vigour hypothesis. Available from Nature Precedings (2009)
  • Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L,Weinberg RA. hSIR2(SIRT1) functions as an NADdependent p53 deacetylase. Cell. 2001 Oct 19;107(2):149-59.
  • Frye RA. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun. 2000 Jul 5;273(2):793-8.
  • Frye RA. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem Biophys Res Commun. 1999 Jun 24;260(1):273-9.
  • Neubauer A, Neubauer B, He M, Effert P, Iglehart D, Frye RA, Liu E. Analysis of gene amplification in archival tissue by differential polymerase chain reaction. Oncogene. 1992 May;7(5):1019-25.
  • O'Bryan JP, Frye RA, Cogswell PC, Neubauer A, Kitch B, Prokop C, Espinosa R 3rd, Le Beau MM, Earp HS, Liu ET. axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol. 1991 Oct;11(10):5016-31.
  • Frye RA, Benz CC, Liu E. Detection of amplified oncogenes by differential polymerase chain reaction. Oncogene. 1989 Sep;4(9):1153-7.