Roy A. Frye, MD, PhD
Associate Professor of Pathology


Dr. Frye is a member of the Division of Pathology at the Veterans Affairs Pittsburgh Healthcare System (VAPHS).

Office Location:
Pittsburgh VA Medical Center
Pathology, 132L-U
University Drive C
Pittsburgh, PA 15240

Contact Information:
Office Telephone: 412-360-6550
Lab Telephone: 412-360-6449
Email: roy.frye@va.gov

Clinical Expertise

  • Liver biopsies - hepatic tumors, fatty liver disease, and transplant pathology
  • Prostate biopsies

Research Interests

  • Sirtuin genes and influence on energy metabolism and aging pathways
  • General mechanisms of aging, health, and longevity
  • Role of cognition in influencing health and longevity (especially in relation to susceptibility to cardiovascular disease, obesity/type2 diabetes, lung cancer, and emphysema)
  • Role of cognition and vagus nerve signaling in controlling systemic inflammation and health and longevity
  • Role of diet, particularly level of fructose consumption, in influencing susceptibility to fatty liver, obesity/type 2 diabetes, systemic inflammation, and cardiovascular disease

Selected Publications

View Dr. Frye's publications on PubMed

Frye, Roy. Cognitive epidemiology of ethnic health and the CHRM2 vagal vigour hypothesis. Available from Nature Precedings http://hdl.handle.net/10101/npre.2009.2862.1 (2009)

Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L,Weinberg RA. hSIR2(SIRT1) functions as an NADdependent p53 deacetylase. Cell. 2001 Oct 19;107(2):149-59.

Frye RA. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun. 2000 Jul 5;273(2):793-8.

Frye RA. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem Biophys Res Commun. 1999 Jun 24;260(1):273-9.

Neubauer A, Neubauer B, He M, Effert P, Iglehart D, Frye RA, Liu E. Analysis of gene amplification in archival tissue by differential polymerase chain reaction. Oncogene. 1992 May;7(5):1019-25.

O'Bryan JP, Frye RA, Cogswell PC, Neubauer A, Kitch B, Prokop C, Espinosa R 3rd, Le Beau MM, Earp HS, Liu ET. axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol. 1991 Oct;11(10):5016-31.

Frye RA, Benz CC, Liu E. Detection of amplified oncogenes by differential polymerase chain reaction. Oncogene. 1989 Sep;4(9):1153-7.