Shashi Donthamsetty, B. Pharm, Ph.D.

Rm. S453, S-BST
200 Lothrop street
Pittsburgh, PA 15261
shd27@pitt.edu
412-383-8787

Research Interests

  1. Mechanisms of Hepatocellular Carcinoma
  2. Liver Growth Regulation

Publications

  1. Donthamsetty S, Mars WM, Anne Orr, Wu C and Michalopoulos GK. Protection Against Fas-induced Fulminant Hepatic Failure in Liver Specific Integrin Linked Kinase Knockout Mice. Comparative Hepatology, 10 (1) 2011.

  2. Bhave VS, Paranjpe S, Bowen WC, Donthamsetty S, Bell AW, Khillian JP and George K. Michalopoulos Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo. Hepatology , 54 (4): 1360-70 2011.

  3. Chih Wen Lin, Wendy M. Mars Shirish Paranjpe, Donthamsetty S, Vishakha S. Bhave Liang I Kang, Anne Orr, William C. Bowen, Aaron W. Bell and George K. Michalopoulos. Hepatocyte Proliferation and Hepatomegaly Induced by Phenobarbital and TCPOBOP is Suppressed in Hepatocyte-Targeted Glypican 3 Transgenic. Hepatology, 2011, 54(2):620-30.

  4. Bhave VS, Donthamsetty S, Latendresse JR, Cunningham ML, Mehendale HM. Secretory phospholipase A(2)-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2. Toxicol Appl Pharmacol. 2011, 251(3):173-80

  5. Donthamsetty S, Bhave VS, Kliment CS, Bowen WC, Mars WM, Bell AW, OrrA, Bhave VB, Wu C and Michalopoulos GK Excessive Hepatomegaly of Mice with Hepatocyte-Targeted Elimination of Integrin Linked Kinase Following Treatment by TCPOBOP. Hepatology, 53(2):587-95 2011.

  6. Donthamsetty S, Bowen WC, Mars WM, Luo JH, OrrA, Bhave VB, Wu C, Michalopoulos GK. Liver Specific Ablation of Integrin Linked Kinase (ILK) in Mice Results in Enhanced and Prolonged cell proliferation and hepatomegaly after Phenobarbital Administration. Toxicological Sciences, 2009: 358-66.

  7. Apte U, Gkretsi V, Bowen WC, Mars WM, Luo JH, Donthamsetty S, Orr A, Monga SP, Wu C, Michalopoulos GK. Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase Hepatology (2009):841-51.

  8. Donthamsetty, S., Bhave, V. S., Mitra, M. S., Latendresse, J. R., and Mehendale, H. M., "Nonalcholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARα with clofibrate," 230 (3) Toxicology and Applied Pharmacology (2008): 327-37.

  9. Donthamsetty, S., Bhave, V. S., Mitra, M. S., Latendresse, J. R., and Mehendale, H. M., "Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity," 45 Hepatology (2007): 391-403.

  10. Bhave, V. S., Donthamsetty, S., Latendresse, J. R., and Mehendale, H. M., "Secretory phospholipase A2 mediates progression of acute liver injury in the absence of sufficient COX-2," 228 Toxicology and Applied Pharmacology (2008): 225-38.

  11. Bhave, V. S., Donthamsetty, S., Latendresse, J. R., and Mehendale, H. M., "Inhigition of COX-2 aggravates secretory phospholipase A2-mediated progression of acute liver injury," 228 Toxicology and Applied Pharmacology (2008): 239-46.

  12. Mitra, M. S., Donthamsetty, S., White, B., and Mehendale, H. M., "High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity," 231 (3) Toxicology and Applied Pharmacology (2008): 413-22.

  13. Mitra, M. S., Donthamsetty, S., Latendresse, J. R., and Mehendale, H. M., "A holistic mechanism of protection of moderately diet restricted rats against acute doxorubicin-induced cardiotoxicity," 225 Toxicology and Applied Pharmacology (2007): 90-101.