Vishakha Bhave, B. Pharm, Ph.D.

Rm. S454, S-BST
200 Lothrop street
Pittsburgh, PA 15261
vsb1@pitt.edu
412-383-8787

Research Interests

  1. To study the role of reprogramming factors (Oct4, Nanog, Klf4) in survival, proliferation, and transdifferentiation of liver epithelial cells (hepatocytes and biliary epithelial cells).
  2. The role of CD81, Glypican 3, and their binding partners in regulation of liver growth.

Publications

  1. Bhave V. S., Shirish Paranjpe, William C. Bowen, Shashikiran Donthamsetty, Aaron W. Bell, Jaspal S. Khillan, and George K. Michalopoulos. Genes Inducing iPS Phenotype Play a Role in Hepatocyte Survival and Proliferation in vitro and Liver Regeneration in vivo. Hepatology, 54(4):1360-1370, 2011.

  2. Bhave, V. S., Donthamsetty, S., Latendresse, J. R., Cunningham, M., and Mehendale. H. M. Absence of hepatic COX-2 exacerbates sPLA2- mediated progression of hepatotoxicity initiated by acetaminophen. Toxicol. Appl. Pharmacol. 251: 173-180, 2011.

  3. Donthamsetty S, Bhave V. S., Kliment CS, Bowen WC, Mars WM, Bell AW, OrrA, Bhave VB, Wu C and Michalopoulos GK. Excessive Hepatomegaly of Mice with Hepatocyte-Targeted Elimination of Integrin Linked Kinase Following Treatment by TCPOBOP. Hepatology, 53(2):587-95 2011.

  4. Chih Wen Lin, Wendy M. Mars Shirish Paranjpe, Shashikiran Donthamsetty, Bhave V. S., Liang I Kang, Anne Orr, William C. Bowen, Aaron W. Bell and George K. Michalopoulos. Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice. Hepatology, 54(2):620-30, 2011.

  5. Donthamsetty S, Bowen WC, Mars WM, Luo JH, Orr A, Bhave V. S., Wu C, Michalopoulos GK. Liver Specific Ablation of Integrin Linked Kinase (ILK) in Mice Results in Enhanced and Prolonged cell proliferation and hepatomegaly after Phenobarbital Administration. Toxicological Sciences, 113(2):358-366, 2010.

  6. Bhave, V. S., Donthamsetty S., Latendresse J. R., and Mehendale H. M. Secretory phospholipase A2 mediates progression of acute liver injury in the absence of sufficient COX-2. Toxicol. Appl. Pharmacol., 228(2):225-38, 2008.

  7. Bhave, V. S., Donthamsetty S., Latendresse J. R., and Mehendale H. M. Inhibition of COX-2 aggravates secretory phospholipase A2-mediated progression of acute liver injury. Toxicol. Appl. Pharmacol., 228(2):239-46, 2008.

  8. Donthamsetty, S., Bhave, V. S., Mitra, M. S., Latendresse, J. R., and Mehendale HM. Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARalpha with clofibrate. Toxicol. Appl. Pharmacol., 230(3):327-37, 2008.

  9. Donthamsetty, S., Bhave, V. S., Mitra M. S., Latendresse, J. R., and Mehendale, H. M. Non alcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity. Hepatology, 45(2):391-403, 2007.

  10. Limaye P. B., Bhave V. S., Palkar P. S., Apte U. M., Sawant S. P., Yu S., Latendresse J. R., Reddy J. K., and Mehendale H. M. Upregulation of calpastatin in regenerating and developing livers: Role in resistance against hepatotoxicity. Hepatology, 44(2):379-388, 2006.